Factors for poor oral health in long-term childhood cancer survivors.
Factors for poor oral health in long-term childhood cancer survivors.
复制标题
长期儿童癌症幸存者口腔健康状况不佳的因素。
DOI：
10.1186/s12903-023-02762-0
复制
发表时间：
2023-02-04
期刊：
影响因子：
2.9
通讯作者：
Robison, Leslie L.
中科院分区：
文献类型：
--
作者：
Patni, Tushar;Lee, Chun-Teh;Li, Yimei;Kaste, Sue;Zhu, Liang;Sun, Ryan;Hudson, Melissa M.;Ness, Kirsten K.;Neumann, Ana;Robison, Leslie L.
儿童癌症幸存者面临与治疗相关的牙科疾病的风险。该研究的目的是调查圣裘德终身队列 (SJLIFE) 参与者的临床、社会经济和人口因素与口腔疾病之间的关联。我们对参与 St. Jude 终生队列 (SJLIFE) 研究的 4856 名儿童癌症幸存者和 591 名社区对照者进行了回顾性医疗图表审查并评估了纵向自我报告的牙科结果。使用单变量和多变量逻辑回归模型来评估社会经济因素、治疗暴露和患者人口统计对牙科结果的影响。癌症幸存者更有可能报告小牙（比值比 (OR) = 7.89，95% 置信区间 (CI) [4.64，14.90]）、牙根发育异常（OR = 6.19，CI [3.38，13.00]）、牙齿发育不全（OR = 2.75，CI [1.83， 4.33]），牙釉质发育不全（OR = 4.24，CI [2.9，6.49]），口干症（OR = 7.72，CI [3.27，25.10]），严重牙龈炎（OR = 2.04，CI [1.43，3.03]），与无癌症史的对照组相比，缺失牙齿≥≥6颗（OR = 3.73，CI [2.46，6.00]）。接受经典烷化剂（OR = 1.6，CI [1.36，1.88]）、蒽环类抗生素（OR = 1.22，CI [1.04，1.42]）或可能暴露口腔的放射治疗（OR = 1.48，CI [1.26，1.72]）的幸存者更有可能报告至少一颗牙齿在控制了社会经济因素、最后一次随访和诊断的年龄、其他治疗暴露以及获得牙科服务的机会后，接受过可能暴露口腔的放射治疗的幸存者也更有可能报告至少一种软组织异常。与没有癌症病史的对照组相比，口腔牙齿异常的患病率更高，社会经济因素和获得口腔保健的机会导致牙齿异常的患病率。
Survivors of childhood cancer are at risk for therapy-related dental diseases. The purpose of the study was to investigate the associations between clinical, socioeconomic, and demographic factors and oral diseases in the St. Jude Lifetime Cohort (SJLIFE) participants. We performed a retrospective medical chart review and evaluated longitudinal self-reported dental outcomes in 4856 childhood cancer survivors and 591 community controls participating in the St. Jude Lifetime Cohort (SJLIFE) study. Univariate and multivariable logistic regression models were used to assess the impact of socioeconomic factors, treatment exposures and patient demographics on dental outcomes. Cancer survivors were more likely to report microdontia (odds ratio (OR) = 7.89, 95% confidence interval (CI) [4.64, 14.90]), abnormal root development (OR = 6.19, CI [3.38, 13.00]), hypodontia (OR = 2.75, CI [1.83, 4.33]), enamel hypoplasia (OR = 4.24, CI [2.9, 6.49]), xerostomia (OR = 7.72, CI [3.27, 25.10]), severe gingivitis (OR = 2.04, CI [1.43, 3.03]), and ≥ 6 missing teeth (OR = 3.73, CI [2.46, 6.00]) compared to controls without cancer history. Survivors who received classic alkylating agents (OR = 1.6, CI [1.36, 1.88]), anthracycline antibiotics (OR = 1.22, CI [1.04, 1.42] or radiation therapy potentially exposing the oral cavity (OR = 1.48, CI [1.26, 1.72]) were more likely to report at least one dental health problem after controlling for socioeconomic factors, age at last follow-up and diagnosis, other treatment exposures, and access to dental services. Survivors who had radiation therapy potentially exposing the oral cavity (OR = 1.52, CI [1.25, 1.84]) were also more likely to report at least one soft tissue abnormality after controlling for socioeconomic factors, age at last follow-up and diagnosis, other treatment exposures, and access and utilization of dental services. Childhood cancer survivors have a higher prevalence of oral-dental abnormalities than the controls without a cancer history. Cancer treatment, socioeconomic factors, and access to oral health care contribute to the prevalence of dental abnormalities.
登录
查看更多内容
影响因子：
3.2
作者：
Hudson, Melissa M.;Ness, Kirsten K.;Nolan, Vikki G.;Armstrong, Gregory T.;Green, Daniel M.;Morris, E. Brannon;Spunt, Sheri L.;Metzger, Monika L.;Krull, Kevin R.;Klosky, James L.;Srivastava, Deo Kumar;Robison, Leslie L.
通讯作者：
Robison, Leslie L.
影响因子：
3.2
作者：
Wogelius, Pia;Dahllof, Goran;Poulsen, Sven
通讯作者：
Poulsen, Sven
影响因子：
--
作者：
Chattopadhyay, Amit
通讯作者：
Chattopadhyay, Amit
儿童癌症幸存者的口腔和牙齿后期影响：儿童肿瘤小组报告。
影响因子：
3.1
作者：
Effinger, Karen E.;Migliorati, Cesar A.;Hudson, Melissa M.;McMullen, Kevin P.;Kaste, Sue C.;Ruble, Kathy;Guilcher, Gregory M. T.;Shah, Ami J.;Castellino, Sharon M.
通讯作者：
Castellino, Sharon M.
男性和口腔健康：性别和性别差异的综述。
DOI：
10.1177/15579883211016361
发表时间：
2021-05
期刊：
American journal of men's health
影响因子：
--
作者：
Lipsky MS;Su S;Crespo CJ;Hung M
通讯作者：
Hung M