Tobacco and alcohol as risk factors for pancreatic cancer.
Tobacco and alcohol as risk factors for pancreatic cancer.
复制标题
DOI：
10.1016/j.bpg.2017.09.001
复制
发表时间：
2017-10
期刊：
影响因子：
--
通讯作者：
Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)
中科院分区：
文献类型：
--
作者：
Korc M;Jeon CY;Edderkaoui M;Pandol SJ;Petrov MS;Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)
预计到2050年，胰腺癌将成为癌症死亡的主要原因。通过改变生活方式的危险因素（最明显的是吸烟），患胰腺癌的风险可降低27%。基于对普通人群中超过200万未选择个体的分析，本文量化了胰腺癌的风险与终生吸烟和饮酒状况的关系，无论是单独的还是联合的。它还提供了关于烟草烟雾和酒精对胰腺前体病变基因工程小鼠模型的影响的动物研究的最新综述，以及胰腺星状细胞和免疫细胞在烟草和酒精激活的胰腺癌发生中的作用。
Pancreatic cancer is projected to become the leading cause of cancer deaths by 2050. The risk for pancreatic cancer may be reduced by up to 27% by modifying lifestyle risk factors, most notably tobacco smoking. Based on analysis of more than 2 million unselected individuals from general population, this article quantified the risk of pancreatic cancer in relation to lifelong tobacco smoking and alcohol consumption status, both alone and in combination. It also provided a state-of-the-art review of animal studies on the effect of tobacco smoke and alcohol on genetically engineered mouse models of pancreatic precursor lesions, as well as the role of pancreatic stellate cells and immune cells in pancreatic carcinogenesis activated by tobacco and alcohol.
登录
查看更多内容
影响因子：
29.4
作者：
Apte MV;Wilson JS;Lugea A;Pandol SJ
通讯作者：
Pandol SJ
影响因子：
5.1
作者：
Gallicchio, L;Kouzis, A;Alberg, AJ
通讯作者：
Alberg, AJ
影响因子：
15.9
作者：
Collins, Meredith A.;Bednar, Filip;di Magliano, Marina Pasca
通讯作者：
di Magliano, Marina Pasca
影响因子：
8
作者：
通讯作者：
--
在一项大型队列研究中，健康的健康生活方式评分和胰腺癌的风险。
影响因子：
--
作者：
Jiao, Li;Mitrou, Panagiota N.;Reedy, Jill;Graubard, Barry I.;Hollenbeck, Albert R.;Schatzkin, Arthur;Stolzenberg-Solomon, Rachael
通讯作者：
Stolzenberg-Solomon, Rachael