Increased risk of parkinsonism associated with welding exposure.
Increased risk of parkinsonism associated with welding exposure.
复制标题
DOI：
10.1016/j.neuro.2012.08.011
复制
发表时间：
2012-10
期刊：
影响因子：
3.4
通讯作者：
Checkoway, Harvey
中科院分区：
文献类型：
--
作者：
Racette, Brad A.;Criswell, Susan R.;Lundin, Jessica I.;Hobson, Angela;Seixas, Noah;Kotzbauer, Paul T.;Evanoff, Bradley A.;Perlmutter, Joel S.;Zhang, Jing;Sheppard, Lianne;Checkoway, Harvey
锰（Mn）是一种公认的神经毒物，是焊接烟雾的常见成分。与焊接暴露相关的神经学表型尚未得到很好的描述。以前流行病学证据连接职业焊接帕金森综合征是混合的，仍然存在争议。这是一项横断面和巢式病例对照研究，调查811名造船厂和制造业焊工从工会招募的帕金森综合征的患病率和表型。两个参考组包括59名非焊工贸易工人和118名新诊断的未经治疗的特发性PD患者。由运动障碍专家使用统一帕金森病评定量表运动子部分3（Unified Parkinson Disease Rating Scale motor subsection 3，简称MRS3）对研究受试者进行检查。帕金森综合征病例定义为焊接工，且APRS3评分≥ 15。正常定义为CRRS 3 <6。暴露被分类为强度调整的累积焊接年数。校正后的帕金森综合征患病率与焊接年的四分位数相关。焊接暴露工人帕金森综合征的总体患病率估计为15.6%，而参考组为0%。在焊工中，我们观察到加权焊接工作年限与帕金森病之间的U形剂量反应关系。焊工和新诊断的特发性帕金森病（PD）患者之间大多数领域的UPDRS 3评分相似，除了PD患者的静止性震颤和不对称频率更高。这项在焊工中进行的基于工作现场的研究表明，与非焊接暴露工人相比，帕金森综合征的患病率较高，其临床表型与PD基本重叠。
Manganese (Mn), an established neurotoxicant, is a common component of welding fume. The neurological phenotype associated with welding exposures has not been well described. Prior epidemiologic evidence linking occupational welding to parkinsonism is mixed, and remains controversial. This was a cross-sectional and nested case–control study to investigate the prevalence and phenotype of parkinsonism among 811 shipyard and fabrication welders recruited from trade unions. Two reference groups included 59 non-welder trade workers and 118 newly diagnosed, untreated idiopathic PD patients. Study subjects were examined by a movement disorders specialist using the Unified Parkinson Disease Rating Scale motor subsection 3 (UPDRS3). Parkinsonism cases were defined as welders with UPDRS3 score ≥15. Normal was defined as UPDRS3 < 6. Exposure was classified as intensity adjusted, cumulative years of welding. Adjusted prevalence ratios for parkinsonism were calculated in relation to quartiles of welding years. The overall prevalence estimate of parkinsonism was 15.6% in welding exposed workers compared to 0% in the reference group. Among welders, we observed a U-shaped dose–response relation between weighted welding exposure-years and parkinsonism. UPDRS3 scores for most domains were similar between welders and newly diagnosed idiopathic Parkinson disease (PD) patients, except for greater frequency of rest tremor and asymmetry in PD patients. This work-site based study among welders demonstrates a high prevalence of parkinsonism compared to nonwelding-exposed workers and a clinical phenotype that overlaps substantially with PD.
登录
查看更多内容
影响因子：
2
作者：
Hobson AJ;Sterling DA;Emo B;Evanoff BA;Sterling CS;Good L;Seixas N;Checkoway H;Racette BA
通讯作者：
Racette BA
影响因子：
4.1
作者：
Harris, Rachel C.;Lundin, Jessica I.;Racette, Brad A.
通讯作者：
Racette, Brad A.
影响因子：
1.6
作者：
Matheson, LN;Bohr, PC;Hart, DL
通讯作者：
Hart, DL
影响因子：
3.4
作者：
Myers, JE;teWaterNaude, J;Thompson, ML
通讯作者：
Thompson, ML
影响因子：
4.9
作者：
Criswell SR;Perlmutter JS;Huang JL;Golchin N;Flores HP;Hobson A;Aschner M;Erikson KM;Checkoway H;Racette BA
通讯作者：
Racette BA