Actinobacteriophages: Genomics, Dynamics, and Applications.
Actinobacteriophages: Genomics, Dynamics, and Applications.
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DOI：
10.1146/annurev-virology-122019-070009
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发表时间：
2020-09-29
影响因子：
11.3
通讯作者：
Hatfull GF
中科院分区：
文献类型：
--
作者：
Hatfull GF
放线菌噬菌体是放线菌门中感染细菌宿主的病毒。已经描述了超过17，000种放线菌噬菌体，并报道了超过3，000个完整的基因组序列，这些都是大规模，高影响力，综合研究教育计划的结果，例如科学教育联盟噬菌体猎人推进基因组学和进化科学（SEA-PHAGES）计划。它们的基因组多样性是巨大的;放线菌噬菌体包括许多具有不同DNA序列的结构嵌合基因组。它们的基因组多样性是由噬菌体和宿主之间高度动态的相互作用驱动的，并且前噬菌体可以赋予各种防御系统以抵御遗传上不同的噬菌体的攻击;噬菌体可以通过编码反防御蛋白来中和这些防御系统。这些研究不仅提供了对多样性和动态噬菌体群体的见解，而且为分枝杆菌遗传学提供了许多工具。一项使用三噬菌体混合物治疗耐药结核分枝杆菌患者的病例研究表明，结核分枝杆菌可能具有相当大的治疗分枝杆菌感染的潜力。
Actinobacteriophages are viruses that infect bacterial hosts in the phylum Actinobacteria. More than 17,000 actinobacteriophages have been described and over 3,000 complete genome sequences reported, resulting from largescale, high-impact, integrated research-education initiatives such as the Science Education Alliance Phage Hunters Advancing Genomics and Evolutionary Sciences (SEA-PHAGES) program. Their genomic diversity is enormous; actinobacteriophages comprise many architecturally mosaic genomes with distinct DNA sequences. Their genome diversity is driven by the highly dynamic interactions between phages and their hosts, and prophages can confer a variety of systems that defend against attack by genetically distinct phages; phages can neutralize these defense systems by coding for counter-defense proteins. These phages not only provide insights into diverse and dynamic phage populations but also have provided numerous tools for mycobacterial genetics. A case study using a three-phage cocktail to treat a patient with a drug-resistant Mycobacterium abscessus suggests that phages may have considerable potential for the therapeutic treatment of mycobacterial infections.
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DOI：
10.4161/bact.18778
发表时间：
2012-01-01
期刊：
Bacteriophage
影响因子：
--
作者：
Marinelli LJ;Hatfull GF;Piuri M
通讯作者：
Piuri M
影响因子：
3.6
作者：
Dedrick RM;Mavrich TN;Ng WL;Cervantes Reyes JC;Olm MR;Rush RE;Jacobs-Sera D;Russell DA;Hatfull GF
通讯作者：
Hatfull GF
影响因子：
16
作者：
Broussard, Gregory W.;Oldfield, Lauren M.;Hatfull, Graham F.
通讯作者：
Hatfull, Graham F.
DOI：
10.1126/science.aar4120
发表时间：
2018-03-02
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Doron S;Melamed S;Ofir G;Leavitt A;Lopatina A;Keren M;Amitai G;Sorek R
通讯作者：
Sorek R
影响因子：
2.8
作者：
Bardarov, S;Bardarov, S;Jacobs, WR
通讯作者：
Jacobs, WR