Integrins Regulate Responsiveness to Slit Repellent Signals
Integrins Regulate Responsiveness to Slit Repellent Signals
复制标题
整合素调节对狭缝排斥信号的反应
作者：
Adrienne Stevens;J. Jacobs;C. Goodman;Roger Jacobs
整合素集中在生长锥内，但它们对轴突延伸和寻路的贡献尚不清楚。单个整合素的遗传损伤并不阻止生长锥的延伸或运动，但会增加轴突的去纤维化和轴突束移位。在这项研究中，我们记录了一个剂量依赖性的表型之间的相互作用的基因整合素，其配体，中线生长锥排斥，狭缝，但不是中线引诱，Netrin。果蝇胚胎中的纵束轴突为slit和整合素基因（编码αPS1、αPS2、αPS3或βPS1）的双杂合型，沿异位轨迹穿过中枢神经系统中线。果蝇双杂合子的slit和基因编码的整合素配体层粘连蛋白A和Tiggrin揭示了类似的错误，中线轴突的指导。我们建议，从整合素的粘合剂信号的强度的影响阈值的反应由生长锥排斥轴突的指导线索。
Integrins are concentrated within growth cones, but their contribution to axon extension and pathfinding is unclear. Genetic lesion of individual integrins does not stop growth cone extension or motility, but does increase axon defasciculation and axon tract displacement. In this study, we document a dosage-dependent phenotypic interaction between genes for the integrins, their ligands, and the midline growth cone repellent, Slit, but not for the midline attractant, Netrin. Longitudinal tract axons inDrosophila embryos doubly heterozygous forslit and an integrin gene, encoding αPS1, αPS2, αPS3, or βPS1, take ectopic trajectories across the midline of the CNS. Drosophila doubly heterozygous forslit and the genes encoding the integrin ligands Laminin A and Tiggrin reveal similar errors in midline axon guidance. We propose that the strength of adhesive signaling from integrins influences the threshold of response by growth cones to repellent axon guidance cues.
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DOI：
10.1073/pnas.91.24.11447
发表时间：
1994-11-22
影响因子：
11.1
作者：
GOTWALS, PJ;FESSLER, LI;HYNES, RO
通讯作者：
HYNES, RO
影响因子：
4.6
作者：
T. Bunch;M. Graner;L. Fessler;J. Fessler;K. D. Schneider;A. Kerschen;L. P. Choy;B. Burgess;D. Brower
通讯作者：
T. Bunch;M. Graner;L. Fessler;J. Fessler;K. D. Schneider;A. Kerschen;L. P. Choy;B. Burgess;D. Brower
影响因子：
7.5
作者：
Hemler, ME
通讯作者：
Hemler, ME
影响因子：
4.6
作者：
Campos, Fabiana Cerqueira;Dennis, Cynthia;Mirouse, Vincent
通讯作者：
Mirouse, Vincent