Optogenetic fMRI reveals distinct, frequency-dependent networks recruited by dorsal and intermediate hippocampus stimulations.
Optogenetic fMRI reveals distinct, frequency-dependent networks recruited by dorsal and intermediate hippocampus stimulations.
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DOI：
10.1016/j.neuroimage.2014.10.039
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发表时间：
2015-02-15
期刊：
影响因子：
5.7
通讯作者：
Lee JH
中科院分区：
文献类型：
--
作者：
Weitz AJ;Fang Z;Lee HJ;Fisher RS;Smith WC;Choy M;Liu J;Lin P;Rosenberg M;Lee JH
虽然海马回路的连通性已被广泛研究，但这些连接引起大规模动态网络活动的方式仍然未知。在这里，我们使用光遗传学功能磁共振成像可视化的两个不同的神经元群体的背侧和中间海马内的不同频率的刺激引起的脑网络动力学。刺激中间海马的兴奋性细胞引起广泛的皮质和皮质下招募在高频率，而在背侧海马的刺激导致活动主要限于海马在所有测试的频率。在视频脑电图实验中，在高频刺激任一位置期间诱发的持续海马反应预测了癫痫样后放电，而高频刺激中间海马诱发的广泛激活预测了行为癫痫发作。一个负BOLD信号在背侧，但不是中间，海马刺激齿状回观察到的这些差异的机制提出的基础。总的来说，我们的研究结果提供了洞察海马网络的动态功能及其在癫痫发作中的作用。
Although the connectivity of hippocampal circuits has been extensively studied, the way in which these connections give rise to large-scale dynamic network activity remains unknown. Here, we used optogenetic fMRI to visualize the brain network dynamics evoked by different frequencies of stimulation of two distinct neuronal populations within dorsal and intermediate hippocampus. Stimulation of excitatory cells in intermediate hippocampus caused widespread cortical and subcortical recruitment at high frequencies, whereas stimulation in dorsal hippocampus led to activity primarily restricted to hippocampus across all frequencies tested. Sustained hippocampal responses evoked during high-frequency stimulation of either location predicted seizure-like afterdischarges in video-EEG experiments, while the widespread activation evoked by high-frequency stimulation of intermediate hippocampus predicted behavioral seizures. A negative BOLD signal observed in dentate gyrus during dorsal, but not intermediate, hippocampus stimulation is proposed to underlie the mechanism for these differences. Collectively, our results provide insight into the dynamic function of hippocampal networks and their role in seizures.
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