Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures.
Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures.
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DOI：
10.1038/s41467-022-35535-4
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发表时间：
2023-01-10
影响因子：
16.6
通讯作者：
Blumenfeld, Hal
中科院分区：
文献类型：
--
作者：
McCafferty, Cian;Gruenbaum, Benjamin F.;Tung, Renee;Li, Jing-Jing;Zheng, Xinyuan;Salvino, Peter;Vincent, Peter;Kratochvil, Zachary;Ryu, Jun Hwan;Khalaf, Aya;Swift, Kohl;Akbari, Rashid;Islam, Wasif;Antwi, Prince;Johnson, Emily A.;Vitkovskiy, Petr;Sampognaro, James;Freedman, Isaac G.;Kundishora, Adam;Depaulis, Antoine;David, Francois;Crunelli, Vincenzo;Sanganahalli, Basavaraju G.;Herman, Peter;Hyder, Fahmeed;Blumenfeld, Hal
失神发作是意识受损、行为停止和反应迟钝的短暂发作，其神经机制尚不清楚。在这里，我们报告了清醒的雌性大鼠模型概括了人类失神发作的行为，脑电图和皮质功能磁共振成像特征。在神经元方面，癫痫发作的特征是皮质和丘脑中的神经元的整体减少但有节奏的放电。单个皮质和丘脑神经元表达四种不同的癫痫相关活动模式之一，其中一种导致癫痫发作时整体放电的短暂初始峰值，另一种导致整体放电持续下降。发作前40-60 s，低频脑电图活动、神经元放电和行为开始下降，而高频脑电图活动和神经元放电节律性增加。我们的研究结果表明，长时间的大脑状态变化之前的意识损害癫痫发作，癫痫发作期间不同的功能组的皮层和丘脑神经元产生一个整体短暂的放电增加，随后持续放电减少，并增加节律性。失神发作通过未知的神经机制损害意识。在这里，作者发现大鼠失神发作模型的行为和血流动力学概括了先前报道的人类失神发作的特征，并揭示了意识损害发作期间皮质和丘脑中神经元活动的四种不同模式。
Absence seizures are brief episodes of impaired consciousness, behavioral arrest, and unresponsiveness, with yet-unknown neuronal mechanisms. Here we report that an awake female rat model recapitulates the behavioral, electroencephalographic, and cortical functional magnetic resonance imaging characteristics of human absence seizures. Neuronally, seizures feature overall decreased but rhythmic firing of neurons in cortex and thalamus. Individual cortical and thalamic neurons express one of four distinct patterns of seizure-associated activity, one of which causes a transient initial peak in overall firing at seizure onset, and another which drives sustained decreases in overall firing. 40–60 s before seizure onset there begins a decline in low frequency electroencephalographic activity, neuronal firing, and behavior, but an increase in higher frequency electroencephalography and rhythmicity of neuronal firing. Our findings demonstrate that prolonged brain state changes precede consciousness-impairing seizures, and that during seizures distinct functional groups of cortical and thalamic neurons produce an overall transient firing increase followed by a sustained firing decrease, and increased rhythmicity. Absence seizures impair consciousness by an unknown neuronal mechanism. Here, the authors find that a rat absence seizure model’s behavior and hemodynamics recapitulate previously reported characteristics of human absence seizures, and uncover four distinct patterns of neuronal activity in cortex and thalamus during consciousness-impairing seizures.
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影响因子：
5.6
作者：
Ding L;Gallagher MJ
通讯作者：
Gallagher MJ
影响因子：
5.6
作者：
Blumenfeld, H
通讯作者：
Blumenfeld, H
影响因子：
5.7
作者：
Archer, JS;Abbott, DF;Jackson, GD
通讯作者：
Jackson, GD
DOI：
10.1523/jneurosci.5101-09.2010
发表时间：
2010-04-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bai X;Vestal M;Berman R;Negishi M;Spann M;Vega C;Desalvo M;Novotny EJ;Constable RT;Blumenfeld H
通讯作者：
Blumenfeld H
影响因子：
4.3
作者：
Burton H;Reeder RM;Holden T;Agato A;Firszt JB
通讯作者：
Firszt JB