Dynamics of sensorimotor cortex activation during absence and myoclonic seizures in a mouse model of juvenile myoclonic epilepsy.
Dynamics of sensorimotor cortex activation during absence and myoclonic seizures in a mouse model of juvenile myoclonic epilepsy.
复制标题
DOI：
10.1111/epi.13493
复制
发表时间：
2016-10
期刊：
影响因子：
5.6
通讯作者：
Gallagher MJ
中科院分区：
文献类型：
--
作者：
Ding L;Gallagher MJ
广泛性癫痫综合征通常会导致多种类型的癫痫发作，但尚不清楚这些癫痫发作是激活单独的还是重叠的脑网络。最近，我们报道了具有幼年型肌阵挛性癫痫突变[Gabra1(A322D)]的小鼠表现出缺失和肌阵挛性全身性癫痫发作。在此，我们测定了两次发作时感觉运动皮层激活的时间过程和尖峰电压的空间分布。我们将Gabra1+/A322D小鼠在双侧体感觉皮质桶状区（S1）和前（aM1）、后（pM1）运动皮质植入多个脑电图电极，记录失神发作/尖波放电（SWDs）和肌阵挛发作。我们使用非线性关联分析和互相关计算来确定从前期到后期状态以及峰间和峰间期皮质耦合的强度、主导区域和时间延迟。在SWDs和肌阵挛发作时也测量了尖峰电压的分布。所有电极对的脑电图连通性在SWDs和肌阵挛发作时都增加。令人惊讶的是，在两种发作类型的尖峰期间，S1以相似的延迟时间领先M1。肌阵挛性发作尖峰比SWD尖峰更局部地开始，绝大多数只出现在S1电极，而相当一部分SWD尖峰首先出现在S1和至少一个M1电极。肌阵挛性发作尖峰的绝对电压明显高于SWD尖峰，且在肌阵挛性发作尖峰期间M1上的相对电压高于前1 ~ 2个SWD尖峰。S1的领先位点和相似的延迟时间表明，SWDs和肌阵挛性发作都激活了感觉运动皮层的重叠网络，因此，靶向该网络的治疗可能会治疗这两种癫痫发作。峰值聚焦，绝对电压和电压分布提供了在这两种癫痫发作类型中神经元激活的洞察力。
Generalized epilepsy syndromes often confer multiple types of seizures, but it is not known if these seizures activate separate or overlapping brain networks. Recently, we reported that mice with a juvenile myoclonic epilepsy mutation [Gabra1(A322D)] exhibited both absence and myoclonic generalized seizures. Here, we determined the time course of sensorimotor cortex activation and the spatial distribution of spike voltage during these two seizures. We implanted Gabra1+/A322D mice with multiple EEG electrodes over bilateral somatosensory cortex barrel fields (S1) and anterior (aM1) and posterior (pM1) motor cortices and recorded absence seizures / spike-wave discharges (SWDs) and myoclonic seizures. We used nonlinear-association analyses and cross-correlation calculations to determine the strength, leading regions, and time delays of cortical coupling from the preictal to ictal states and within the spike and interspike periods. The distribution of spike voltage was also measured in SWDs and myoclonic seizures. EEG connectivity among all electrode pairs increased at the onset of both SWDs and myoclonic seizures. Surprisingly, during spikes of both seizure types, S1 led M1 with similar delay times. Myoclonic seizure spikes started more focally than SWD spikes with a significant majority appearing first only in S1 electrodes while a substantial fraction of SWD spikes were detected first in S1 and at least one M1 electrode. The absolute voltage of myoclonic seizure spikes was significantly higher than that of SWD spikes and there was a greater relative voltage over M1 during myoclonic seizure spikes than in the first one to two SWD spikes. The leading sites in S1 and similar delay times suggest both SWDs and myoclonic seizures activate overlapping networks in sensorimotor cortex and thus, therapeutically targeting this network could potentially treat both seizures. Spike focality, absolute voltage and voltage distribution provide insight into neuronal activation during these two seizure types.
登录
查看更多内容
影响因子：
9.9
作者：
Senf, Philine;Schmitz, Bettina;Janz, Dieter
通讯作者：
Janz, Dieter
细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
影响因子：
3.1
作者：
Best, Christoph;Lange, Elena;Dieterich, Marianne
通讯作者：
Dieterich, Marianne
影响因子：
5.6
作者：
Bourgeois, Blaise F. D.;Douglass, Laurie M.;Sankar, Raman
通讯作者：
Sankar, Raman
影响因子：
16.2
作者：
Ferezou, Isabelle;Haiss, Florent;Petersen, Carl C. H.
通讯作者：
Petersen, Carl C. H.