Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance.
Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance.
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Piezo1通道感知全身体育活动以重置心血管稳态并提高性能。
DOI：
10.1038/s41467-017-00429-3
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发表时间：
2017-08-24
影响因子：
16.6
通讯作者：
Beech DJ
中科院分区：
文献类型：
--
作者：
Rode B;Shi J;Endesh N;Drinkhill MJ;Webster PJ;Lotteau SJ;Bailey MA;Yuldasheva NY;Ludlow MJ;Cubbon RM;Li J;Futers TS;Morley L;Gaunt HJ;Marszalek K;Viswambharan H;Cuthbertson K;Baxter PD;Foster R;Sukumar P;Weightman A;Calaghan SC;Wheatcroft SB;Kearney MT;Beech DJ
哺乳动物的生物学适应身体活动，但感知活动的分子机制仍然是个谜。最近的研究揭示了 Piezo1 蛋白如何感知机械力以促进血管发育。在这里，我们研究成人内皮细胞中的 Piezo1，它是身体活动的主要控制位点。没有内皮Piezo1的小鼠缺乏明显的表型，但仔细观察发现对肠系膜阻力动脉的内皮依赖性松弛有特定的作用。引人注目的是，Piezo1 是全身身体活动期间血压升高所必需的，但不活动期间血压却不需要。 Piezo1 负责流动敏感的非失活非选择性阳离子通道，使膜电位去极化。随着流体流量增加，去极化增加，激活邻近血管平滑肌细胞中的电压门控 Ca2+ 通道，引起血管收缩。缺乏内皮 Piezo1 的小鼠的身体机能会受到影响，并且持续活动后体重会减轻。数据表明 Piezo1 通道感知身体活动，以有利地重置血管控制。人们对调节身体对运动反应的机制知之甚少。在这里，罗德等人。研究表明，机械激活的阳离子通道 Piezo1 是内皮细胞中物理运动的分子传感器，可触发内皮细胞与肠系膜血管肌肉细胞的通讯，从而导致血管收缩。
Mammalian biology adapts to physical activity but the molecular mechanisms sensing the activity remain enigmatic. Recent studies have revealed how Piezo1 protein senses mechanical force to enable vascular development. Here, we address Piezo1 in adult endothelium, the major control site in physical activity. Mice without endothelial Piezo1 lack obvious phenotype but close inspection reveals a specific effect on endothelium-dependent relaxation in mesenteric resistance artery. Strikingly, the Piezo1 is required for elevated blood pressure during whole body physical activity but not blood pressure during inactivity. Piezo1 is responsible for flow-sensitive non-inactivating non-selective cationic channels which depolarize the membrane potential. As fluid flow increases, depolarization increases to activate voltage-gated Ca2+ channels in the adjacent vascular smooth muscle cells, causing vasoconstriction. Physical performance is compromised in mice which lack endothelial Piezo1 and there is weight loss after sustained activity. The data suggest that Piezo1 channels sense physical activity to advantageously reset vascular control. The mechanisms that regulate the body’s response to exercise are poorly understood. Here, Rode et al. show that the mechanically activated cation channel Piezo1 is a molecular sensor of physical exercise in the endothelium that triggers endothelial communication to mesenteric vessel muscle cells, leading to vasoconstriction.
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影响因子：
16.6
作者：
Coste, Bertrand;Murthy, Swetha E.;Mathur, Jayanti;Schmidt, Manuela;Mechioukhi, Yasmine;Delmas, Patrick;Patapoutian, Ardem
通讯作者：
Patapoutian, Ardem
DOI：
10.1249/mss.0b013e3181923957
发表时间：
2009-05-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Thijssen, Dick H. J.;Dawson, Ellen A.;Green, Daniel J.
通讯作者：
Green, Daniel J.
影响因子：
16.6
作者：
Fotiou E;Martin-Almedina S;Simpson MA;Lin S;Gordon K;Brice G;Atton G;Jeffery I;Rees DC;Mignot C;Vogt J;Homfray T;Snyder MP;Rockson SG;Jeffery S;Mortimer PS;Mansour S;Ostergaard P
通讯作者：
Ostergaard P
影响因子：
20.1
作者：
Lavie CJ;Arena R;Swift DL;Johannsen NM;Sui X;Lee DC;Earnest CP;Church TS;O'Keefe JH;Milani RV;Blair SN
通讯作者：
Blair SN
影响因子：
5.5
作者：
Ahn, Sang Joon;Fancher, Ibra S.;Levitan, Irena
通讯作者：
Levitan, Irena