Rational design of biodegradable thermoplastic polyurethanes for tissue repair.
Rational design of biodegradable thermoplastic polyurethanes for tissue repair.
复制标题
DOI：
10.1016/j.bioactmat.2021.11.029
复制
发表时间：
2022-09
影响因子：
18.9
通讯作者：
Hong Y
中科院分区：
文献类型：
--
作者：
Xu C;Hong Y
作为一种弹性聚合物，不可降解的聚氨酯（PUS）具有悠久的历史，可用于诊所，而可生物降解的脓液近几十年来主要用于组织修复和再生。可生物降解的热塑性（线性）脓液是具有高机械强度的柔软和弹性聚合物生物材料，它们模仿了软和弹性组织的机械性能。因此，可生物降解的热塑性聚氨酯是有望的脚手架材料，用于软组织修复和再生。通常，通过连接三种可变的块：二异氰酸酯，二醇和链扩展器来合成脓液。交替的这三个块的组合可以很好地调整物理化学特性并产生新的功能性脓液。这些脓液具有出色的处理灵活性，可以使用常规和/或高级技术制造成三维（3D）构建体，这与交联的热固性弹性体相比是一个很大的优势。此外，它们可以与生物分子结合使用，以纳入所需的生物活性以扩大其生物医学应用。在这篇综述中，我们全面总结了可生物降解的热塑性脓液的合成，结构和特性，并在组织修复和再生中引入了多个应用。他们的设计和应用以及未来方向的讨论和观点将提供理论和技术支持，以激发新的PU开发和新颖的应用。
具有高弹性和良好生物相容性的线性可生物降解聚氨酯已用于软弹性组织。
可以通过设计和改变化学结构来有效地提供和调整可生物降解聚氨酯的生物结构和特性，并且它们也可以很容易地将其处理成理想的体系结构。
对于未来的开发和可生物降解弹性聚氨酯在组织修复中的开发和应用，预计将进行新的化学和进一步评估。
As a type of elastomeric polymers, non-degradable polyurethanes (PUs) have a long history of being used in clinics, whereas biodegradable PUs have been developed in recent decades, primarily for tissue repair and regeneration. Biodegradable thermoplastic (linear) PUs are soft and elastic polymeric biomaterials with high mechanical strength, which mimics the mechanical properties of soft and elastic tissues. Therefore, biodegradable thermoplastic polyurethanes are promising scaffolding materials for soft and elastic tissue repair and regeneration. Generally, PUs are synthesized by linking three types of changeable blocks: diisocyanates, diols, and chain extenders. Alternating the combination of these three blocks can finely tailor the physio-chemical properties and generate new functional PUs. These PUs have excellent processing flexibilities and can be fabricated into three-dimensional (3D) constructs using conventional and/or advanced technologies, which is a great advantage compared with cross-linked thermoset elastomers. Additionally, they can be combined with biomolecules to incorporate desired bioactivities to broaden their biomedical applications. In this review, we comprehensively summarized the synthesis, structures, and properties of biodegradable thermoplastic PUs, and introduced their multiple applications in tissue repair and regeneration. A whole picture of their design and applications along with discussions and perspectives of future directions would provide theoretical and technical supports to inspire new PU development and novel applications. Linear biodegradable polyurethanes with high elasticity and good biocompatibility have been utilized for soft and elastic tissue repair. The biofunctions and characteristics of biodegradable polyurethanes can be effectively offered and tuned through designing and altering chemical structures, and they also can be easily processed into desirable architectures. New chemistry and further evaluations are expected for future development and applications of biodegradable elastic polyurethanes in tissue repair.
登录
查看更多内容
影响因子：
3.7
作者：
Boffito M;Di Meglio F;Mozetic P;Giannitelli SM;Carmagnola I;Castaldo C;Nurzynska D;Sacco AM;Miraglia R;Montagnani S;Vitale N;Brancaccio M;Tarone G;Basoli F;Rainer A;Trombetta M;Ciardelli G;Chiono V
通讯作者：
Chiono V
影响因子：
9.7
作者：
Ashton, J. H.;Mertz, J. A. M.;Vande Geest, J. P.
通讯作者：
Vande Geest, J. P.
影响因子：
7.4
作者：
Andorko JI;Jewell CM
通讯作者：
Jewell CM
影响因子：
9.7
作者：
Battiston, K. G.;Labow, R. S.;Santerre, J. P.
通讯作者：
Santerre, J. P.
由壳聚糖功能化 PLGA 微球制成的可生物降解圆柱形棒中的超声调制形状记忆和有效负载释放效应
影响因子：
6.2
作者：
Bao, Min;Zhou, Qihui;Zhang, Yanzhong
通讯作者：
Zhang, Yanzhong