Night eating model shows time-specific depression-like behavior in the forced swimming test.
Night eating model shows time-specific depression-like behavior in the forced swimming test.
复制标题
夜间饮食模型在强制游泳测试中显示了特定时间的抑郁症行为。
DOI：
10.1038/s41598-018-19433-8
复制
发表时间：
2018-01-18
影响因子：
4.6
通讯作者：
Shibata S
中科院分区：
文献类型：
--
作者：
Haraguchi A;Fukuzawa M;Iwami S;Nishimura Y;Motohashi H;Tahara Y;Shibata S
生物钟系统与进食和情绪有关。夜间进食综合征（内斯）患者的进食节律延迟，情绪在傍晚和夜间下降，表现为时间特异性抑郁。因此，我们假设内斯喂养模式可能会导致时间特异性抑郁症。在正常脂肪饮食的基础上，于非活动期限制高脂饮食，建立新的内斯模型。内斯模型组强迫游泳不动时间仅在开灯后延长，与人类的傍晚和深夜相对应。我们使用PER 2：：LUCIFERASE基因敲入小鼠和体内监测系统研究了内斯喂养模式对外周时钟的影响。非活动期的热量摄入会改变外周生物钟，可能是导致时间特异性抑郁样行为的一个重要因素。内斯模型组应激时5-羟色胺和去甲肾上腺素合成增加，单胺类物质利用和代谢减少。地昔帕明可缩短内斯模型组部分小鼠的FST不动时间。本研究表明，内斯喂养模式导致外周生物钟的相位偏移和单胺系统的功能障碍，这可能有助于特定时间抑郁症的发展。
The circadian clock system is associated with feeding and mood. Patients with night eating syndrome (NES) delay their eating rhythm and their mood declines during the evening and night, manifesting as time-specific depression. Therefore, we hypothesized that the NES feeding pattern might cause time-specific depression. We established new NES model by restricted feeding with high-fat diet during the inactive period under normal-fat diet ad libitum. The FST (forced swimming test) immobility time in the NES model group was prolonged only after lights-on, corresponding to evening and early night for humans. We examined the effect of the NES feeding pattern on peripheral clocks using PER2::LUCIFERASE knock-in mice and an in vivo monitoring system. Caloric intake during the inactive period would shift the peripheral clock, and might be an important factor in causing the time-specific depression-like behavior. In the NES model group, synthesis of serotonin and norepinephrine were increased, but utilization and metabolism of these monoamines were decreased under stress. Desipramine shortened some mice’s FST immobility time in the NES model group. The present study suggests that the NES feeding pattern causes phase shift of peripheral clocks and malfunction of the monoamine system, which may contribute to the development of time-specific depression.
登录
查看更多内容
影响因子：
9.3
作者：
Calabrese, Francesca;Savino, Elisa;Riva, Marco A.
通讯作者：
Riva, Marco A.
影响因子：
3.4
作者：
BORSINI, F;LECCI, A;MELI, A
通讯作者：
MELI, A
影响因子：
0.4
作者：
Abou-Elnaga, Ahmed F.;Torigoe, Daisuke;Agui, Takashi
通讯作者：
Agui, Takashi
影响因子：
2.8
作者：
Allison, Kelly C.;Studt, Stacia K.;Stunkard, Albert J.
通讯作者：
Stunkard, Albert J.
夜间饮食综合症女性的昼夜节律概况。
影响因子：
3.5
作者：
Goel N;Stunkard AJ;Rogers NL;Van Dongen HP;Allison KC;O'Reardon JP;Ahima RS;Cummings DE;Heo M;Dinges DF
通讯作者：
Dinges DF