Interrelationships among the MTHFR 677C>T polymorphism, migraine, and cardiovascular disease.
Interrelationships among the MTHFR 677C>T polymorphism, migraine, and cardiovascular disease.
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MTHFR 677C> T多态性，偏头痛和心血管疾病之间的相互关系。
DOI：
10.1212/01.wnl.0000316198.34558.e5
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发表时间：
2008-08-12
期刊：
影响因子：
9.9
通讯作者：
Kurth T
中科院分区：
文献类型：
--
作者：
Schürks M;Zee RY;Buring JE;Kurth T
MTHFR 677C >t多态性（rs1801133）与偏头痛和心血管疾病（CVD）之间的相互关系似乎是合理的，但仍存在争议。参与妇女健康研究的25001名美国白人妇女的关联研究，MTHFR 677C>T多态性的信息。偏头痛和偏头痛先兆状态是自我报告的。事件CVD事件在医疗记录审查后得到确认。我们使用逻辑回归来研究基因型与偏头痛的关联，并使用比例风险模型来评估基因型和偏头痛对心血管疾病发生的相互关系。基线时，4577名（18.3%）女性报告有偏头痛病史；3226名女性偏头痛患者中39.5%有先兆。在平均11.9年的随访期间，发生了625起心血管疾病事件。我们的研究结果表明TT基因型携带者患先兆偏头痛的风险略有降低。隐性模型的多变量校正相对危险度（RR）为0.79 （95%CI=0.65 ~ 0.96; p=0.02）。TT基因型没有增加心血管疾病的风险。相比之下，先兆偏头痛患者发生心血管疾病的风险增加了一倍（多变量校正RR=2.06; 95%CI= 1.53-2.78; p<0.0001）。先兆偏头痛和TT基因型的共存选择性地增加了这种风险（RR=3.66; 95%CI= 1.69-7.90; p=0.001）。这种模式是由缺血性卒中风险增加4倍驱动的（多变量调整后的RR=4.19; 95%CI= 1.38-12.74; p=0.01），而心肌梗死不明显。来自这一大型女性队列的数据表明，MTHFR 677TT基因型对先兆偏头痛有适度的保护作用。TT基因型携带者在先兆偏头痛患者中CVD风险的增加被放大，这是由缺血性卒中风险的显著增加所驱动的。
Interrelationships between the MTHFR 677C>T polymorphism (rs1801133), migraine, and cardiovascular disease (CVD) are plausible but remain controversial. Association study among 25,001 white U.S. women, participating in the Women’s Health Study, with information on MTHFR 677C>T polymorphism. Migraine and migraine aura status were self-reported. Incident CVD events were confirmed after medical record review. We used logistic regression to investigate the genotype-migraine association and proportional hazards models to evaluate the interrelationships of genotype and migraine on incident CVD. At baseline, 4,577 (18.3%) women reported history of migraine; 39.5% of the 3,226 women with active migraine indicated aura. During a mean of 11.9 years of follow-up, 625 CVD events occurred. Our results suggest a modestly reduced risk for migraine with aura in carriers of the TT genotype. The multivariable-adjusted relative risk (RR) in the recessive model was 0.79 (95%CI=0.65–0.96; p=0.02). The TT genotype did not increase the risk for CVD. In contrast, migraine with aura doubled the risk for CVD (multivariable-adjusted RR=2.06; 95%CI=1.53–2.78; p<0.0001). Co-existence of migraine with aura and the TT genotype selectively raised this risk (RR=3.66; 95%CI=1.69–7.90; p=0.001). This pattern was driven by a 4-fold increased risk for ischemic stroke (multivariable-adjusted RR=4.19; 95%CI=1.38–12.74; p=0.01) and not apparent for myocardial infarction. Data from this large cohort of women suggest a modest protective effect of the MTHFR 677TT genotype on migraine with aura. The increased risk for CVD among migraineurs with aura was magnified for TT genotype carriers, which was driven by a substantially increased risk of ischemic stroke.
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DOI：
10.1016/s0169-328x(02)00672-1
发表时间：
2003-03-17
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Kara, I;Sazci, A;Kilic, G
通讯作者：
Kilic, G
影响因子：
120.7
作者：
Kurth, Tobias;Gaziano, J. Michael;Buring, Julie E.
通讯作者：
Buring, Julie E.
影响因子：
11.2
作者：
Scher, AI;Terwindt, GM;Launer, LJ
通讯作者：
Launer, LJ
影响因子：
4.9
作者：
Bottini, F;Celle, ME;Molinari, AC
通讯作者：
Molinari, AC
DOI：
10.1375/twin.6.5.422
发表时间：
2003-10-01
期刊：
TWIN RESEARCH
影响因子：
--
作者：
Mulder, EJ;van Baal, C;Palotie, A
通讯作者：
Palotie, A