Expression Characteristics and Significant Prognostic Values of PGK1 in Breast Cancer.
Expression Characteristics and Significant Prognostic Values of PGK1 in Breast Cancer.
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DOI：
10.3389/fmolb.2021.695420
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发表时间：
2021
影响因子：
5
通讯作者：
Shen W
中科院分区：
文献类型：
--
作者：
Li Y;Wang S;Zhang X;Yang R;Wei X;Yan R;Jiang Y;Shen W
研究证明PGK1在人类乳腺癌的增殖、迁移和侵袭过程中发挥着至关重要的作用。然而，根据各种乳腺癌患者分类，PGK1 mRNA和蛋白表达与临床病理特征和预后价值的相关性仍然不充分。在这里，我们分析了 Oncomine 数据库、乳腺癌 Gene-Expression Miner v4.5、TNMplot、MuTarget、PrognoScan 数据库和临床生物信息学的数据，以研究 PGK1 在乳腺癌患者中的表达分布和预后价值。我们的研究表明，PGK1 的 mRNA 和蛋白表达水平在乳腺癌的各种临床病理类型中均上调。此外，PGK1的表达与常见抑癌基因TP53和CDH1的突变相关。此外，我们发现 PGK1 的高 mRNA 水平与较差的 OS、RFS 和 DMFS 显着相关。值得注意的是，Cox回归分析表明PGK1可以作为独立的预后标志物。总之，上述研究结果表明PGK1不仅可以作为潜在的生物标志物进行探索，还可以与TP53/CDH1联合用于乳腺癌化疗。
It was proven that PGK1 plays a vital role in the proliferation, migration, and invasion of human breast cancer. However, the correlation of PGK1 mRNA and protein expression with clinicopathologic characteristics and prognostic values according to various kinds of breast cancer patient classifications remains unsufficient. Here, we analyzed data from the Oncomine database, Breast cancer Gene-Expression Miner v4.5, TNMplot, MuTarget, PrognoScan database, and clinical bioinformatics to investigate PGK1 expression distribution and prognostic value in breast cancer patients. Our study revealed that the mRNA and protein expression levels of PGK1 were up-regulated in various clinicopathologic types of breast cancer. Moreover, the expression of PGK1 was correlated with mutations of common tumor suppressor genes TP53 and CDH1. In addition, we found that high mRNA level of PGK1 was significantly associated with poor OS, RFS, and DMFS. Notably, Cox regression analysis showed that PGK1 could be used as an independent prognostic marker. In summary, the aforementioned findings suggested that PGK1 might be not only explored as a potential biomarker, but also combined with TP53/CDH1 for chemotherapy in breast cancer.
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影响因子：
5.2
作者：
Ahmad, Sufian S.;Glatzle, Joerg;Zieker, Derek
通讯作者：
Zieker, Derek
影响因子：
16.2
作者：
Shao, Fei;Yang, Xueying;He, Jie
通讯作者：
He, Jie
影响因子：
6.4
作者：
Lei, HX;Sjöberg-Margolin, S;Vorechovsky, I
通讯作者：
Vorechovsky, I
影响因子：
--
作者：
Ai, Jianzhong;Huang, Huizhe;Zhou, Qin
通讯作者：
Zhou, Qin
DOI：
10.3390/medicines6010017
发表时间：
2019-01-23
期刊：
Medicines (Basel, Switzerland)
影响因子：
--
作者：
Nakhjavani, Maryam;Hardingham, Jennifer E;Townsend, Amanda R
通讯作者：
Townsend, Amanda R