Bone density, geometry, microstructure, and stiffness: Relationships between peripheral and central skeletal sites assessed by DXA, HR-pQCT, and cQCT in premenopausal women.
Bone density, geometry, microstructure, and stiffness: Relationships between peripheral and central skeletal sites assessed by DXA, HR-pQCT, and cQCT in premenopausal women.
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DOI：
10.1002/jbmr.111
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发表时间：
2010-10
期刊：
影响因子：
--
通讯作者：
Guo XE
中科院分区：
文献类型：
--
作者：
Liu XS;Cohen A;Shane E;Yin PT;Stein EM;Rogers H;Kokolus SL;McMahon DJ;Lappe JM;Recker RR;Lang T;Guo XE
高分辨率外周定量计算机断层扫描（HR-pQCT）是一种新的体内成像技术，用于评估桡骨和胫骨远端骨皮质和骨小梁的三维显微结构。目前还没有研究调查HR-pQCT对周围骨骼的测量在多大程度上反映了脊柱和髋关节的测量，而脊柱和髋关节是最严重骨折发生的地方。为了解决这个研究问题，我们对69名绝经前妇女进行了双能量吸收仪（DXA）、中央QCT （cQCT）、HR-pQCT和基于图像的有限元分析，以评估腰椎、股骨近端、桡骨远端和胫骨远端皮质和骨小梁骨密度、几何形状、微观结构和刚度之间的关系。两个外周部位（r=0.86）、两个中心部位（r=0.49）以及外周和中心骨骼部位（r=0.56-0.70）之间存在显著相关性。这些关联部分可以通过多个骨骼部位之间的面积骨密度（aBMD）、体积骨密度（vBMD）和横截面积（CSA）的显著相关性来解释。对于股骨近端刚度的预测，通过HR-pQCT测量胫骨远端vBMD （r=0.75）和刚度（r=0.69）与直接测量股骨近端相当：通过DXA测量髋关节aBMD （r=0.70）和通过cQCT测量髋关节vBMD （r=0.64）。对于椎体刚度的预测，HR-pQCT的骨小梁vBMD （r=0.58）和桡骨远端刚度（r=0.70）与直接测量腰椎相当：DXA测量的aBMD （r=0.78）和cQCT测量的vBMD （r=0.67）。我们的研究结果表明，通过HR-pQCT测量的桡骨远端和胫骨的骨密度、显微结构和力学性能反映了中央骨骼的力学能力。
High-resolution peripheral quantitative computed tomography (HR-pQCT) is a new in vivo imaging technique for assessing three-dimensional microstructure of cortical and trabecular bone at the distal radius and tibia. No studies have investigated the extent to which measurements of the peripheral skeleton by HR-pQCT reflect those of the spine and hip, where the most serious fractures occur. To address this research question, we performed dual energy absorptiometry (DXA), central QCT (cQCT), HR-pQCT, and image-based finite element analyses in 69 premenopausal women to evaluate relationships among cortical and trabecular bone density, geometry, microstructure, and stiffness of the lumbar spine, proximal femur, distal radius and distal tibia. Significant correlations were found between stiffness of the two peripheral sites (r=0.86), two central sites (r=0.49), and between peripheral and central skeletal sites (r=0.56-0.70). These associations were partially explained by significant correlations in areal BMD (aBMD), volumetric BMD (vBMD), and cross-sectional area (CSA) between the multiple skeletal sites. For prediction of proximal femoral stiffness, vBMD (r=0.75) and stiffness (r=0.69) of the distal tibia by HR-pQCT were comparable to direct measurements of the proximal femur: aBMD of hip by DXA (r=0.70) and vBMD of hip by cQCT (r=0.64). For prediction of vertebral stiffness, trabecular vBMD (r=0.58) and stiffness (r=0.70) of distal radius by HR-pQCT were comparable to direct measurements of lumbar spine: aBMD by DXA (r=0.78) and vBMD by cQCT (r=0.67). Our results suggest that bone density, microstructural and mechanical properties measured by HR-pQCT of the distal radius and tibia reflect mechanical competence of the central skeleton.
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DOI：
10.1097/01.blo.0000164400.37905.22
发表时间：
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影响因子：
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作者：
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