Potency of an inactivated influenza vaccine prepared from A/duck/Hokkaido/162/2013 (H2N1) against a challenge with A/swine/Missouri/2124514/2006 (H2N3) in mice.
Potency of an inactivated influenza vaccine prepared from A/duck/Hokkaido/162/2013 (H2N1) against a challenge with A/swine/Missouri/2124514/2006 (H2N3) in mice.
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DOI：
10.1292/jvms.17-0312
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发表时间：
2017-11-10
期刊：
影响因子：
--
通讯作者：
Sakoda Y
中科院分区：
文献类型：
--
作者：
Suzuki M;Okamatsu M;Hiono T;Matsuno K;Sakoda Y
H2N2 流感病毒从 1957 年开始引起大流行，但自 1968 年以来一直没有在人类中检测到。因此，大多数人对 H2 亚型病毒的免疫反应是幼稚的。相比之下，H2流感病毒不断从野生鸟类中分离出来，H2N3病毒于2006年从猪身上分离出来。H2流感病毒如果重新引入人类可能会引起大流行。在本研究中，制备了一种针对 H2 流感的疫苗，作为预防未来人类大流行的有效控制措施。 A/duck/Hokkaido/162/2013 (H2N1)表现出广泛的抗原交叉反应性，是从最近从亚洲国家的野生鸟类中分离出的候选H2流感病毒中选出的。两次皮下注射灭活的全病毒颗粒疫苗后，小鼠体内诱导出足够的针对同源和异源病毒的中和抗体。灭活疫苗诱导的保护性免疫足以减少 A/swine/Missouri/2124514/2006 (H2N3) 攻击的影响。这项研究表明，从流感病毒库制备的灭活全病毒颗粒疫苗将有助于预防未来的 H2 流感大流行。
H2N2 influenza virus caused a pandemic starting in 1957 but has not been detected in humans since 1968. Thus, most people are immunologically naive to viruses of the H2 subtype. In contrast, H2 influenza viruses are continually isolated from wild birds, and H2N3 viruses were isolated from pigs in 2006. H2 influenza viruses could cause a pandemic if re-introduced into humans. In the present study, a vaccine against H2 influenza was prepared as an effective control measure against a future human pandemic. A/duck/Hokkaido/162/2013 (H2N1), which showed broad antigenic cross-reactivity, was selected from the candidate H2 influenza viruses recently isolated from wild birds in Asian countries. Sufficient neutralizing antibodies against homologous and heterologous viruses were induced in mice after two subcutaneous injections of the inactivated whole virus particle vaccine. The inactivated vaccine induced protective immunity sufficient to reduce the impact of challenges with A/swine/Missouri/2124514/2006 (H2N3). This study demonstrates that the inactivated whole virus particle vaccine prepared from an influenza virus library would be useful against a future H2 influenza pandemic.
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