Periodontal disease increases the host susceptibility to COVID-19 and its severity: a Mendelian randomization study.
Periodontal disease increases the host susceptibility to COVID-19 and its severity: a Mendelian randomization study.
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牙周病增加宿主对 COVID-19 及其严重程度的易感性：孟德尔随机研究
DOI：
10.1186/s12967-021-03198-2
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发表时间：
2021-12-24
影响因子：
7.4
通讯作者：
Huang XF
中科院分区：
文献类型：
--
作者：
Wang Y;Deng H;Pan Y;Jin L;Hu R;Lu Y;Deng W;Sun W;Chen C;Shen X;Huang XF
新的证据表明，牙周病（PD）可能会增加2019冠状病毒病（COVID-19）并发症的风险。在这里，我们进行了一项双样本孟德尔随机化（MR）研究，并首次调查了PD对宿主对COVID-19易感性及其严重程度的可能因果影响。从COVID-19宿主遗传学倡议中检索COVID-19易感性和严重程度的汇总统计数据，并将其用作结局。全基因组关联研究中与PD相关的单核苷酸多态性被纳入暴露。采用逆方差加权（IVW）方法作为分析PD与COVID-19之间因果关系的主要方法。采用了三种额外的方法，允许存在水平多效性，包括MR-Egger回归，加权中位数和加权模式方法。还进行了全面的敏感性分析，以估计所确定的关联的稳健性。使用IVW（OR = 1.024，P = 0.017，95%CI 1.004-1.045）和加权中位数法（OR = 1.029，P = 0.024，95%CI 1.003-1.055）进行MR估计显示，PD与显著更高的COVID-19易感性显著相关。此外，基于住院与人群对照的比较，它显示PD与COVID-19严重程度显著相关（IVW，OR = 1.025，P = 0.039，95%CI 1.001-1.049;加权中位数，OR = 1.030，P = 0.027，95%CI 1.003-1.058）。在确诊的高度严重病例与未因COVID-19住院的病例队列中未观察到此类关联。我们提供了PD与COVID-19易感性和严重程度之间可能因果关系的证据，强调了在大流行期间及之后口腔/牙周保健对整体健康的重要性。
Emerging evidence shows that periodontal disease (PD) may increase the risk of Coronavirus disease 2019 (COVID-19) complications. Here, we undertook a two-sample Mendelian randomization (MR) study, and investigated for the first time the possible causal impact of PD on host susceptibility to COVID-19 and its severity. Summary statistics of COVID-19 susceptibility and severity were retrieved from the COVID-19 Host Genetics Initiative and used as outcomes. Single nucleotide polymorphisms associated with PD in Genome-wide association study were included as exposure. Inverse-variance weighted (IVW) method was employed as the main approach to analyze the causal relationships between PD and COVID-19. Three additional methods were adopted, allowing the existence of horizontal pleiotropy, including MR-Egger regression, weighted median and weighted mode methods. Comprehensive sensitivity analyses were also conducted for estimating the robustness of the identified associations. The MR estimates showed that PD was significantly associated with significantly higher susceptibility to COVID-19 using IVW (OR = 1.024, P = 0.017, 95% CI 1.004–1.045) and weighted median method (OR = 1.029, P = 0.024, 95% CI 1.003–1.055). Furthermore, it revealed that PD was significantly linked to COVID-19 severity based on the comparison of hospitalization versus population controls (IVW, OR = 1.025, P = 0.039, 95% CI 1.001–1.049; weighted median, OR = 1.030, P = 0.027, 95% CI 1.003–1.058). No such association was observed in the cohort of highly severe cases confirmed versus those not hospitalized due to COVID-19. We provide evidence on the possible causality of PD accounting for the susceptibility and severity of COVID-19, highlighting the importance of oral/periodontal healthcare for general wellbeing during the pandemic and beyond.
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影响因子：
2
作者：
Bowden J;Del Greco M F;Minelli C;Davey Smith G;Sheehan N;Thompson J
通讯作者：
Thompson J
影响因子：
7.6
作者：
Gupta S;Mohindra R;Chauhan PK;Singla V;Goyal K;Sahni V;Gaur R;Verma DK;Ghosh A;Soni RK;Suri V;Bhalla A;Singh MP
通讯作者：
Singh MP
影响因子：
2.1
作者：
Bowden J;Davey Smith G;Haycock PC;Burgess S
通讯作者：
Burgess S
影响因子：
6.7
作者：
Marouf N;Cai W;Said KN;Daas H;Diab H;Chinta VR;Hssain AA;Nicolau B;Sanz M;Tamimi F
通讯作者：
Tamimi F
影响因子：
3.9
作者：
Larvin H;Wilmott S;Wu J;Kang J
通讯作者：
Kang J