The Impact of Periodontal Disease on Hospital Admission and Mortality During COVID-19 Pandemic.
The Impact of Periodontal Disease on Hospital Admission and Mortality During COVID-19 Pandemic.
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DOI：
10.3389/fmed.2020.604980
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发表时间：
2020
影响因子：
3.9
通讯作者：
Kang J
中科院分区：
文献类型：
--
作者：
Larvin H;Wilmott S;Wu J;Kang J
简介：COVID-19对社会和医疗保健产生了巨大的影响，有人认为牙周病患者有可能因这种疾病而导致更糟糕的结果。本研究旨在量化2019冠状病毒病大流行期间牙周病对住院和死亡率的影响。材料与方法：该研究抽取了2020年3月至6月期间接受过COVID-19检测的英国生物库参与者（n = 13，253），其中1，616人为COVID-19阳性（12%），11，637人为COVID-19阴性（88%）。自我报告的牙龈疼痛或出血和牙齿松动的口腔健康指标被用作牙周病的替代品，没有报告任何上述指标的参与者被用作对照。使用多变量logistic回归获得COVID-19感染、随后住院和死亡率的粗比值比和校正比值比，并根据人口统计学、BMI、生物标志物、生活方式和合并症进行校正。结果：2.7%、11.2%和3.3%的COVID-19感染者分别报告了牙龈疼痛、牙龈出血和牙齿松动。与对照组相比，牙龈疼痛或出血以及牙齿松动的参与者的COVID-19感染风险并未增加（比值比[OR]：1.10，95% CI：0.72-1.69; OR：1.15，95% CI：0.84-1.59）。患有牙龈疼痛或出血的COVID-19阳性参与者死亡风险较高（OR：1.71，95% CI：1.05-2.72），但住院风险不高（OR：0.90，95% CI：0.59-1.37）。与对照组相比，牙齿松动的参与者没有表现出更高的住院或死亡风险（OR = 1.55，95% CI：0.87-2.77; OR：1.85; 95% CI：0.92-2.72）。结论：没有足够的证据表明牙周病与COVID-19感染风险增加有关。然而，在COVID-19阳性患者中，患有牙周病的参与者的死亡率明显更高。利用链接的牙科和医院患者记录将提高对牙周病对COVID-19相关结果影响的理解。
Introduction: COVID-19 has had a huge impact on society and healthcare and it has been suggested that people with periodontal disease are at risk of having worse outcomes from the disease. The aim of this study was to quantify the impact of periodontal disease on hospital admission and mortality during the COVID-19 pandemic. Materials and Methods: The study extracted UK Biobank participants who had taken a COVID-19 test between March and June 2020 (n = 13,253), of which 1,616 were COVID-19 positive (12%) and 11,637 were COVID-19 negative (88%). Self-reported oral health indicators of painful or bleeding gums and loose teeth were used as surrogates for periodontal disease, participants who did not report any of the aforementioned indicators were used as controls. Multivariable logistic regressions were used to obtain crude and adjusted odds ratios of COVID-19 infection, subsequent hospital admission and mortality adjusted for demographics, BMI, biomarkers, lifestyle and co-morbidities. Results: Painful gums, bleeding gums and loose teeth were reported in 2.7, 11.2 and 3.3% of participants with COVID-19 infection, respectively. Risk of COVID-19 infection in participants with painful or bleeding gums and loose teeth compared to controls was not increased (odds ratio [OR]: 1.10, 95% CI: 0.72–1.69; OR: 1.15, 95% CI: 0.84–1.59). COVID-19 positive participants with painful or bleeding gums had a higher risk of mortality (OR: 1.71, 95% CI: 1.05–2.72) but not hospital admission (OR: 0.90, 95% CI: 0.59–1.37). Participants with loose teeth did not show higher risk of hospital admission or mortality compared to the control group (OR = 1.55, 95% CI: 0.87–2.77; OR: 1.85; 95% CI: 0.92–2.72). Conclusion: There was insufficient evidence to link periodontal disease with an increased risk of COVID-19 infection. However, amongst the COVID-19 positive, there was significantly higher mortality for participants with periodontal disease. Utilization of linked dental and hospital patient records would improve the understanding of the impact of periodontal disease on COVID-19 related outcomes.
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DOI：
10.1093/ehjqcco/qcaa062
发表时间：
2021-07-01
影响因子：
5.2
作者：
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通讯作者：
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影响因子：
3.2
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Rivas-Tumanyan, Sona;Spiegelman, Donna;Curhan, Gary C.;Forman, John P.;Joshipura, Kaumudi J.
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