The effects of vitamin and mineral supplementation on women with gestational diabetes mellitus.
The effects of vitamin and mineral supplementation on women with gestational diabetes mellitus.
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DOI：
10.1186/s12902-021-00712-x
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发表时间：
2021-05-24
影响因子：
2.7
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Li D;Cai Z;Pan Z;Yang Y;Zhang J
维生素和矿物质补充对妊娠期糖尿病（GDM）妇女的影响尚未得到很好的证实。我们进行了一项荟萃分析，以评估维生素和矿物质补充对GDM女性血糖控制、炎症和氧化应激的影响。系统检索了截至2020年7月PubMed、Embase、Web of Science和Cochrane Library的随机对照试验（RCTs）。使用Review manager 5.3和Stata 12.0对各种结果进行汇总。估计95%置信区间（CI）的均值差（MD）。研究间的异质性通过i平方（I2）检验评估。我们的荟萃分析纳入了来自12项试验的698名患者。与接受安慰剂的女性相比，镁、锌、硒、钙、维生素D和E（单独或联合）显著改善了GDM女性的血糖控制：空腹血糖（FPG） （MD = - 9.02; 95% CI: - 12.09, - 5.96; P < 0.00001），血清胰岛素（MD = - 4.33; 95% CI: - 5.35, - 3.32; P < 0.00001），稳态模型评估-胰岛素抵抗（HOMA-IR） (MD = - 1.34; 95% CI: - 1.60, - 1.07；P < 0.00001)，以及评估β细胞功能的稳态模型（HOMA-B） （MD = - 15.58; 95% CI: - 23.70, - 7.46; P = 0.0002）。维生素和矿物质补充剂通过降低高敏c -反应蛋白（hs-CRP） （MD = - 1.29; 95% CI: - 1.82, - 0.76; P < 0.00001）、丙二醛（MDA） （MD = - 0.71; 95% CI: - 0.97, - 0.45; P < 0.00001）和增加总抗氧化能力（TAC） （MD = 45.55; 95% CI: 22.02, 69.08; P = 0.0001）来减轻炎症和氧化应激。这项荟萃分析显示，补充维生素和矿物质可显著改善GDM女性的血糖控制，减轻炎症和氧化应激。在线版本包含补充材料，可在10.1186/s12902-021-00712-x获得。
The effects of vitamin and mineral supplementation on women with gestational diabetes mellitus (GDM) have not been well established. We conduct a meta-analysis to evaluate the effects of vitamin and mineral supplementation on glycemic control, inflammation and oxidative stress for women with GDM. A systematic search of randomized controlled trials (RCTs) was conducted from PubMed, Embase, Web of Science and Cochrane Library up to July, 2020. Various results were pooled by using Review manager 5.3 and Stata 12.0. Mean difference (MD) with 95% confidence interval (CI) was estimated. Heterogeneity between studies was assessed by I-squared (I2) tests. Six hundred ninety-eight patients from 12 trials were included in our meta-analysis. Magnesium, zinc, selenium, calcium, vitamin D and E (alone or in combination) were found to significantly improve glycemic control in women with GDM compared to those receiving placebos: fasting plasma glucose (FPG) (MD = - 9.02; 95% CI: - 12.09, - 5.96; P < 0.00001), serum insulin (MD = - 4.33; 95% CI: - 5.35, - 3.32; P < 0.00001), homeostasis model assessment-insulin resistance (HOMA-IR) (MD = - 1.34; 95% CI: - 1.60, - 1.07; P < 0.00001), and homeostasis model of assessment for β cell function (HOMA-B) (MD = - 15.58; 95% CI: - 23.70, - 7.46; P = 0.0002). Vitamin and mineral supplementation was found to attenuated inflammation and oxidative stress through decreasing high-sensitivity C-reactive protein (hs-CRP) (MD = - 1.29; 95% CI: - 1.82, - 0.76; P < 0.00001), malondialdehyde (MDA) (MD = - 0.71; 95% CI: - 0.97, - 0.45; P < 0.00001), and increasing total antioxidant capacity (TAC) (MD = 45.55; 95% CI: 22.02, 69.08; P = 0.0001). This meta-analysis shows that vitamin and mineral supplementation significantly improved glycemic control, attenuated inflammation and oxidative stress in women with GDM. The online version contains supplementary material available at 10.1186/s12902-021-00712-x.
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影响因子：
2
作者：
Liu, Y. X.;Guo, Y. M.;Wang, Z.
通讯作者：
Wang, Z.
影响因子：
3.6
作者：
Maestro, B;Molero, S;Calle, C
通讯作者：
Calle, C
影响因子：
7.1
作者：
Asemi, Zatollah;Hashemi, Teibeh;Esmaillzadeh, Ahmad
通讯作者：
Esmaillzadeh, Ahmad
DOI：
10.1016/j.bbrc.2013.06.004
发表时间：
2013-07-19
影响因子：
3.1
作者：
Jain, Sushil K.;Micinski, David
通讯作者：
Micinski, David
影响因子：
4.3
作者：
He, Yu-Tong;Liu, Dian-Wu;Xiao, Yong-Hong
通讯作者：
Xiao, Yong-Hong