Myoblast fusion: when it takes more to make one.
Myoblast fusion: when it takes more to make one.
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DOI：
10.1016/j.ydbio.2009.10.024
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发表时间：
2010-05-01
影响因子：
2.7
通讯作者：
Baylies, Mary K.
中科院分区：
文献类型：
--
作者：
Rochlin, Kate;Yu, Shannon;Roy, Sudipto;Baylies, Mary K.
关键词：
细胞-细胞融合在许多组织的形态和功能的发生中都是一个关键的和高度调控的事件。一种特殊的细胞融合，成肌细胞融合，是塑造肌肉形成和修复的关键细胞过程。尽管它对人类健康很重要，但这一过程背后的机制仍然没有被很好地理解。这篇综述的目的是强调与成肌细胞融合相关的最新文献，并重点比较几个模型系统中的这些研究，特别是苍蝇、斑马鱼和小鼠。技术分析和成像方面的进步使得能够识别新的融合基因，并推动了对每个系统中以前识别的基因的进一步表征。在成肌细胞融合的细胞步骤中，迁移、识别、黏附、膜对齐以及膜孔形成和分辨是关键的步骤。重要的是，引人注目的新证据表明，在这些物种中，有几个步骤是由同源基因控制的。总而言之，对三个模型系统的比较揭示了一个曾经难以捉摸的过程，提供了令人兴奋的新见解和一个有用的基因和机制框架。
Cell-cell fusion is a crucial and highly regulated event in the genesis of both form and function of many tissues. One particular type of cell fusion, myoblast fusion, is a key cellular process that shapes both the formation and repair of muscle. Despite its importance for human health, the mechanisms underlying this process are still not well understood. The purpose of this review is to highlight the recent literature pertaining to myoblast fusion and to focus on a comparison of these studies across several model systems, particularly the fly, zebrafish and mouse. Advances in technical analysis and imaging have allowed identification of new fusion genes and propelled further characterization of previously identified genes in each of these systems. Among the cellular steps identified as critical for myoblast fusion is migration, recognition, adhesion, membrane alignment and membrane pore formation and resolution. Importantly, striking new evidence indicates that orthologous genes govern several of these steps across these species. Taken together, comparisons across three model systems are illuminating a once elusive process, providing exciting new insights and a useful framework of genes and mechanisms.
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影响因子：
4.8
作者：
Bondesen, Brenda A.;Jones, Kristen A.;Pavlath, Grace K.
通讯作者：
Pavlath, Grace K.
DOI：
10.1007/0-387-32963-3_7
发表时间：
2006-01-01
期刊：
MUSCLE DEVELOPMENT IN DROSOPHILA
影响因子：
--
作者：
Carmena, Ana;Baylies, Mary
通讯作者：
Baylies, Mary
影响因子：
30.8
作者：
Baxendale, S;Davison, C;Roy, S
通讯作者：
Roy, S
影响因子：
4
作者：
Berger, Susanne;Schaefer, Gritt;Oenel, Susanne-Filiz
通讯作者：
Oenel, Susanne-Filiz
影响因子：
2.5
作者：
Bryson-Richardson, R;Daggett, DF;Currie, PD
通讯作者：
Currie, PD