Exposure to parental verbal abuse is associated with increased gray matter volume in superior temporal gyrus.
Exposure to parental verbal abuse is associated with increased gray matter volume in superior temporal gyrus.
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DOI：
10.1016/j.neuroimage.2010.05.027
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发表时间：
2011-01
期刊：
影响因子：
5.7
通讯作者：
Teicher, Martin H.
中科院分区：
文献类型：
--
作者：
Tomoda, Akemi;Sheu, Yi-Shin;Rabi, Keren;Suzuki, Hanako;Navalta, Carryl P.;Polcari, Ann;Teicher, Martin H.
儿童时期接触父母言语攻击(PVA)会增加患精神病的风险，特别是情绪和焦虑症。其他形式的儿童期虐待也被发现与大脑结构的改变有关。这项研究的目的是确定接触PVA是否与大脑形态的可辨别影响有关。对21名有PVA病史的未用药的右利手受试者(18-25岁)和19名年龄和性别相当的精神健康对照组进行了基于优化体素的形态测量。使用高分辨率、T1加权的体积MRI数据集(西门子3T Trio扫描仪)评估灰质体积(GMV)的组间差异--GMV随年龄、性别、父母教育程度、经济压力和总GMV而变化。左侧颞上回GMV增加14.1%(P=0.004，校正簇水平)。GMV与母亲的言语攻击(β=0.544，P<；0.0001)和父亲的言语攻击(β=0.300，P<；0.02)密切相关，与父母的教育程度(β=−=0.577，P<；0.0001)负相关。以前的研究表明，有虐待史的儿童STG GMV增加，并发现接触PVA的年轻人连接Wernicke‘s区和额区的弓形束的各向异性分数减少。这些发现和目前的结果表明，参与语言加工的听觉联想皮质的发育可能受到早期应激和/或情绪辱骂语言的影响。
Exposure to parental verbal aggression (PVA) during childhood increases risk for the development of psychopathology, particularly mood and anxiety disorders. Other forms of childhood abuse have been found to be associated with alterations in brain structure. The aim of this study was to ascertain whether exposure to PVA was associated with discernible effects on brain morphology. Optimized voxel based morphometry was performed on 21 unmedicated, right-handed subjects (18–25 years) with histories of PVA and 19 psychiatrically healthy controls of comparable age and gender. Group differences in gray matter volume (GMV) – covaried by age, gender, parental education, financial stress, and total GMV – were assessed using high-resolution, T1-weighted, volumetric MRI data sets (Siemens 3T trio scanner). GMV was increased by 14.1% in the left superior temporal gyrus (STG, BA 22) (P = 0.004, corrected cluster level). GMV in this cluster was associated most strongly with levels of maternal (β = 0.544, P < 0.0001) and paternal (β = 0.300, P < 0.02) verbal aggression and inversely associated with parental education (β = −0.577, P < 0.0001). Previous studies have demonstrated an increase in STG GMV in children with abuse histories, and found a reduction in fractional anisotropy in the arcuate fasciculus connecting Wernicke’s and frontal areas in young adults exposed to PVA. These findings and the present results suggest that the development of auditory association cortex involved in language processing may be affected by exposure to early stress and/or emotionally-abusive language.
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影响因子：
4.8
作者：
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通讯作者：
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暴露于父母言语虐待的年轻人中白质异常的初步证据。
影响因子：
10.6
作者：
Choi, Jeewook;Jeong, Bumseok;Rohan, Michael L.;Polcari, Ann M.;Teicher, Martin H.
通讯作者：
Teicher, Martin H.