Stimulant medication and substance use outcomes: a meta-analysis.
Stimulant medication and substance use outcomes: a meta-analysis.
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DOI：
10.1001/jamapsychiatry.2013.1273
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发表时间：
2013-07
期刊：
影响因子：
25.8
通讯作者：
Lee SS
中科院分区：
文献类型：
--
作者：
Humphreys KL;Eng T;Lee SS
精神兴奋剂阳离子是一种有效的治疗儿童注意力缺陷/多动障碍，但仍有争议的潜在医源性影响的兴奋剂阳离子，特别是在增加易感性，后来的物质使用障碍。然而，兴奋剂治疗以前被报道可以降低物质问题的风险。荟萃分析儿童时期使用兴奋剂阳离子治疗与以后的物质结果（即，终生物质使用和物质滥用或依赖）之间的纵向关联。1980年1月至2012年2月期间发表的研究使用综述文章、PubMed和相关列表服务进行识别。采用纵向设计的研究，其中阳离子治疗先于物质结局的测量。比值比由研究作者提取或提供。从15个不同的研究中获得了2565名参与者终生使用（曾经使用）和滥用或依赖酒精、可卡因、大麻、尼古丁和非特异性药物的比值比。随机效应模型估计了总体关联，并对潜在的研究调节因素进行了检查。对每种物质的结果进行了单独的随机效应分析，每种结果的研究数量从3到11不等。结果表明，有和没有阳离子治疗史的儿童之间的任何物质使用和滥用或依赖结果在所有物质类型的可比结果。这些结果提供了一个重要的更新，并表明，治疗注意力缺陷/多动障碍与兴奋剂阳离子既不保护，也不增加以后的物质使用障碍的风险。
Psychostimulant cation is an efficacious treatment for childhood attention-deficit/hyperactivity disorder, yet controversy remains regarding potential iatrogenic effects of stimulant cation, particularly with respect to increasing susceptibility to later substance use disorders. However, stimulant treatment was previously reported to reduce the risk of substance problems. To meta-analyze the longitudinal association between treatment with stimulant cation during childhood and later substance outcomes (ie, lifetime substance use and substance abuse or dependence). Studies published between January 1980 and February 2012 were identified using review articles, PubMed, and pertinent listservs. Studies with longitudinal designs in which cation treatment preceded the measurement of substance outcomes. Odds ratios were extracted or provided by the study authors. Odds ratios were obtained for lifetime use (ever used) and abuse or dependence status for alcohol, cocaine, marijuana, nicotine, and nonspecific drugs for 2565 participants from 15 different studies. Random-effects models estimated the overall association, and potential study moderators were examined. Separate random-effects analyses were conducted for each substance outcome, with the number of studies ranging from 3 to 11 for each outcome. Results suggested comparable outcomes between children with and without cation treatment history for any substance use and abuse or dependence outcome across all substance types. These results provide an important update and suggest that treatment of attention-deficit/hyperactivity disorder with stimulant cation neither protects nor increases the risk of later substance use disorders.
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DOI：
10.1037//0022-006x.70.5.1086
发表时间：
2002-10-01
影响因子：
5.9
作者：
Hinshaw, SP
通讯作者：
Hinshaw, SP
影响因子：
0.6
作者：
Golden, Shawn M.
通讯作者：
Golden, Shawn M.
影响因子：
7.6
作者：
Brandon, CL;Marinelli, M;White, FJ
通讯作者：
White, FJ
影响因子：
8
作者：
Biederman, J;Wilens, T;Faraone, SV
通讯作者：
Faraone, SV
影响因子：
3.3
作者：
Huss, M.;Poustka, F.;Lehmkuhl, U.
通讯作者：
Lehmkuhl, U.