A reverse translational approach to quantify approach-avoidance conflict in humans.
A reverse translational approach to quantify approach-avoidance conflict in humans.
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DOI：
10.1016/j.bbr.2011.08.003
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发表时间：
2011-12-01
影响因子：
2.7
通讯作者：
Stein, Murray B.
中科院分区：
文献类型：
--
作者：
Aupperle, Robin L.;Sullivan, Sarah;Melrose, Andrew J.;Paulus, Martin P.;Stein, Murray B.
动物的趋近 - 回避冲突范式已被广泛用于表征抗焦虑药物的效果以及探究与焦虑相关的神经回路。然而，用于测量人类群体冲突的行为方法却很少，这限制了将动物冲突任务的研究结果转化到人类临床研究中。我们开发了一种新的趋近 - 回避冲突（AAC）范式，该范式涉及同一决策与“奖励”（分数）和“惩罚”（负面情感刺激）相关的情境。95名年轻成年人（56名女性）完成了AAC任务，他们自我报告的特质焦虑水平各不相同。正如预期的那样，与冲突相关的趋近行为与自我报告的趋近奖励和避免惩罚的动机相关，并且更高的奖励水平会增加趋近行为。此外，女性表现出比男性更少的趋近行为。焦虑敏感指数（身体分量表）得分与男性的趋近行为呈负相关，而行为激活量表（BAS，寻求乐趣分量表）得分与女性的趋近行为呈正相关。结果支持AAC任务作为一种具有强大反向转化特征的行为测试的实用性。研究结果表明，趋近驱力和焦虑敏感性可能分别在决定女性和男性的冲突行为中起重要作用。趋近 - 回避冲突任务提供了一种新颖的、可转化的测量方法，用于探究冲突行为、动机过程和焦虑障碍背后的神经系统。
Animal approach-avoidance conflict paradigms have been used extensively to characterize effects of anxiolytic agents and probe neural circuitry related to anxiety. However, there are few behavioral approaches to measure conflict in human populations, limiting the translation of findings from animal conflict tasks to human clinical research. We developed a novel approach-avoidance conflict (AAC) paradigm involving situations in which the same decision is associated with “reward” (points) and “punishment” (negative affective stimuli). The AAC task was completed by 95 young adults (56 female) with varying levels of self-reported trait anxiety. As expected, conflict-related approach behavior correlated with self-reported motivation to approach reward and avoid punishment and greater reward level increased approach behavior. Additionally, females exhibited less approach behavior than males. Anxiety Sensitivity Index (Physical subscale) scores related negatively to approach behavior for males, while Behavioral Activation Scale (BAS, Fun Seeking subscale) scores related positively to approach behavior for females. Results support the utility of the AAC task as a behavioral test that has strong reverse translational features. Findings indicate that approach drives and anxiety sensitivity may be important in determining conflict behavior for females and males respectively. The approach-avoidance conflict task offers a novel, translational measure to probe neural systems underlying conflict behavior, motivational processes, and anxiety disorders.
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影响因子：
5.9
作者：
Gomez, R;Gomez, A;Cooper, A
通讯作者：
Cooper, A
影响因子：
8.2
作者：
BLANCHARD, DC;SHEPHERD, JK;BLANCHARD, RJ
通讯作者：
BLANCHARD, RJ
影响因子：
4.1
作者：
Daughters, Stacey B.;Reynolds, Elizabeth K.;Lejuez, C. W.
通讯作者：
Lejuez, C. W.
DOI：
10.1053/scnp.2001.22927
发表时间：
2001-07-01
期刊：
Seminars in clinical neuropsychiatry
影响因子：
--
作者：
Bechara, A
通讯作者：
Bechara, A
影响因子：
12.8
作者：
Cisler JM;Koster EH
通讯作者：
Koster EH