Faecal microbiota composition associates with abdominal pain in the general population.
Faecal microbiota composition associates with abdominal pain in the general population.
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DOI：
10.1136/gutjnl-2017-314792
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发表时间：
2018-04
期刊：
影响因子：
24.5
通讯作者：
D'Amato M
中科院分区：
文献类型：
--
作者：
Hadizadeh F;Bonfiglio F;Belheouane M;Vallier M;Sauer S;Bang C;Bujanda L;Andreasson A;Agreus L;Engstrand L;Talley NJ;Rafter J;Baines JF;Walter S;Franke A;D'Amato M
我们怀着极大的兴趣阅读了Simrén等人最近的通讯，1报告了功能性GI疾病（FGID）中内脏高敏感性与GI症状严重程度之间的相关性。以前，已经表明内脏高敏感性可以在动物模型中调节甚至诱导，通过用抗生素或来自IBS供体的粪便移植改变其肠道微生物群的组成。因此，虽然肠道微生物群组成与内脏疼痛之间的直接联系可能需要最终确定，但这在IBS和其他FGID的治疗中具有巨大的转化利用潜力。到目前为止，微生物群与人类腹痛之间的潜在关联仅在一项包括15名个体的研究中进行了研究。4为此目的，我们研究了来自瑞典基于人群的结肠镜检查（PopCol）队列的159名个体（平均年龄59.1岁，39.6%男性），先前描述了粪便微生物群16 S测序数据和在同一时期（7.41±7.91天）收集的腹痛（发作次数，持续时间和强度）的每日记录。5-7其中，52人（分配到病例组）报告至少有一次轻度，中度或剧烈疼痛（分别为1，2和3分），而其他107人（对照组）从未报告疼痛。平均而言，疼痛患者每天经历0.30次（范围0.07-1.57），每次持续2.46小时（范围0.37-9），每次发作的强度为1.39（范围1-2.1）。当比较时，在属和物种水平操作分类单位（OTU）的水平上，来自病例和对照的粪便微生物群的β多样性测量值显著不同（图1）。此外，检测到频率、持续时间和强度的疼痛指数与微生物群β多样性的显著相关性（图1）。根据聚集成肠型的微生物群概况对个体进行分类（http：//enterotyping. embl. de）导致三个组，分别富集未分类的瘤胃球菌科、普雷沃氏菌和拟杆菌。如图2所示，χ2分析显示它们在病例和对照组中的分布显著不同（p= 0.039），疼痛组中以普氏菌为主的肠型代表性不足（21% vs 41%）。当先前在动物模型和临床研究中与腹部症状相关的分类群（拟杆菌属、未分类的瘤胃球菌科、丁酸球菌属、普雷沃氏菌属、粪杆菌属、链球菌属、双歧杆菌属、布劳特氏菌属、阿克曼氏菌属、乳杆菌属、Alistipes和肠杆菌属）与Wilcoxon秩和检验进行比较时，
We read with great interest the recent communication by Simrén et al, 1 reporting a correlation between visceral hypersensitivity and GI symptom severity in functional GI disorders (FGID). Previously, it has been shown that visceral hypersensitivity can be modulated or even induced in animal models, by altering the composition of their gut microbiota with antibiotics or faecal transplantation from IBS donors. 2 3 Hence, while a direct link between gut microbiota composition and visceral pain may need to be conclusively established, this holds great potential for translational exploitation in the treatment of IBS and other FGID. Thus far, the potential association between microbiota and abdominal pain in humans has only been investigated in one study that included 15 individuals. 4 For this purpose, we studied 159 individuals (average age 59.1, 39.6% men) from the Swedish Population-based Colonoscopy (PopCol) cohort, previously described and with faecal microbiota 16S sequencing data and daily recordings of abdominal pain (number of episodes, duration and intensity) collected over the same period (7.41±7.91 days). 5–7 Among these, 52 individuals (assigned to the case group) reported at least one episode of light, moderate or intense pain (respective scores 1, 2 and 3), while the other 107 (controls) never reported pain. On average, those with pain experienced it 0.30 times per day (range 0.07–1.57), for 2.46 hours each time (range 0.37–9) and on a light-moderate intensity level of 1.39 per episode (range 1–2.1). When compared, both at the level of genus and species-level operational taxonomic units (OTU), β-diversity measures of faecal microbiota from cases and controls significantly differed (figure 1). In addition, significant correlations with microbiota β-diversity were detected for pain indices of frequency, duration and intensity (figure 1). Classifying individuals according to their microbiota profiles clustered into enterotypes(http://enterotyping. embl. de) resulted in three groups, respectively, enriched for unclassified Ruminococcaceae, Prevotella and Bacteroides. As shown in figure 2, a χ2 analysis revealed their distribution to be significantly different in cases and controls (p= 0.039), and the Prevotella-predominant enterotype was underrepresented in the pain group (21% vs 41% in controls). When taxa previously associated with abdominal symptoms in animal models and clinical studies (Bacteroides, unclassified Ruminococcaceae, Butyricicoccus, Prevotella, Faecalibacterium, Streptococcus, Bifidobacterium, Blautia, Akkermansia, Lactobacillus, Alistipes and Enterobacter) were compared with a Wilcoxon rank-sum test for their
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影响因子：
3.5
作者：
Aguilera, M.;Vergara, P.;Martinez, V.
通讯作者：
Martinez, V.
影响因子：
29.4
作者：
Tap, Julien;Derrien, Muriel;Simren, Magnus
通讯作者：
Simren, Magnus
DOI：
10.1097/meg.0000000000000024
发表时间：
2014-03-01
影响因子：
2.1
作者：
Kjellstrom, Lars;Molinder, Herdis;Andreasson, Anna
通讯作者：
Andreasson, Anna
影响因子：
24.5
作者：
Simren, Magnus;Toernblom, Hans;Whitehead, William E.
通讯作者：
Whitehead, William E.
影响因子：
3.5
作者：
Crouzet, L.;Gaultier, E.;Bernalier-Donadille, A.
通讯作者：
Bernalier-Donadille, A.