Non-alcoholic fatty liver disease is an influencing factor for the association of SHBG with metabolic syndrome in diabetes patients.
Non-alcoholic fatty liver disease is an influencing factor for the association of SHBG with metabolic syndrome in diabetes patients.
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DOI：
10.1038/s41598-017-15232-9
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发表时间：
2017-11-06
影响因子：
4.6
通讯作者：
Hu Y
中科院分区：
文献类型：
--
作者：
Hua X;Li M;Pan F;Xiao Y;Cui W;Hu Y
代谢综合征(MS)和非酒精性脂肪性肝病(NAFLD)是影响血清性激素结合球蛋白(SHBG)水平的危险因素。我们进行了这项横断面研究，以确定MS或NAFLD对2型糖尿病(T2D)患者循环SHBG水平的影响更大。测定血清SHBG、睾酮(TT)、肝酶、血脂、胰岛素、C肽、血糖等人体测量和生化指标。无论MS状态如何，非酒精性脂肪肝患者的SHBG水平均显著低于非酒精性脂肪肝患者(P <； 0.001)。在多元线性回归分析中，较低的血清SHBG水平与较高的NAFLD发生率密切相关，但与MS成分无关。Logistic回归分析显示，调整年龄、性别、糖尿病病程、吸烟状况、饮酒等因素后，合并MS的OR值和95%CI分别为2.2 6(95%CI 1.91~2.6 8)和6.36(95%CI 4.87~8.3 1)，且每例SD降低1例(P 和 均为0.001)。总而言之，在T2D患者中，与MS和其他代谢紊乱相比，血清SHBG降低与NAFLD的患病率更高相关。NAFLD可能是T2D患者循环SHBG与MS相关性的重要影响因素。
Metabolic syndrome (MS) and non-alcoholic fatty liver disease (NAFLD) have been identified as risk factors affecting serum sex hormone binding globulin (SHBG) levels. We conducted this cross-sectional study to delineate whether MS or NAFLD has more impact on circulating SHBG levels in type 2 diabetes (T2D) patients. Anthropometric and biochemical parameters including serums SHBG, testosterone (TT), liver enzymes, lipids, insulin, C-peptide and plasma glucose were measured. Regardless of the MS status, SHBG level was significantly lower in NAFLD patients than in non-NAFLD patients (P < 0.001). In the multiple linear regression analysis, lower serum SHBG level was strongly correlated with a higher incidence of NAFLD, but not MS components. In logistic regression analyses, after adjusted for age, sex, duration of diabetes, smoking status, and alcohol use, the ORs and 95%CI for presence of MS was 2.26 (95%CI 1.91–2.68) and for presence of NAFLD was 6.36 (95%CI 4.87–8.31) with per one SD decrease in serum SHBG (both P < 0.001). In conclusion, lower serum SHBG is associated with a higher prevalence of NAFLD, compared with MS and other metabolic disorders, in T2D patients. NAFLD might be an important influencing factor for the association of circulating SHBG with MS in T2D patients.
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