ColabFold: making protein folding accessible to all.

ColabFold: making protein folding accessible to all.
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DOI:
10.1038/s41592-022-01488-1
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发表时间:
2022-06
期刊:
影响因子:
48
通讯作者:
Steinegger, Martin
Steinegger, Martin
中科院分区:
生物学1区
文献类型:
--
作者:
Mirdita, Milot;Schutze, Konstantin;Moriwaki, Yoshitaka;Heo, Lim;Ovchinnikov, Sergey;Steinegger, Martin

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ColabFold通过将MMseqs 2与AlphaFold 2或RoseTTAFold的快速同源性搜索相结合,提供了对蛋白质结构和复合物的加速预测。ColabFold的搜索速度提高了40 - 60倍,优化了模型利用率,在一台带有图形处理单元的服务器上,每天可以预测近1,000个结构。与Google Colaboratory相结合,ColabFold成为一个免费的蛋白质折叠平台。ColabFold是一个开源软件,可在https://github.com/sokrypton/ColabFold上获得,其新颖的环境数据库可在www.example.com上获得。https://colabfold.mmseqs.com ColabFold是一个免费且可访问的蛋白质折叠平台,可使用AlphaFold 2或RoseTTAFold加速蛋白质结构和复合物的预测。
ColabFold offers accelerated prediction of protein structures and complexes by combining the fast homology search of MMseqs2 with AlphaFold2 or RoseTTAFold. ColabFold’s 40−60-fold faster search and optimized model utilization enables prediction of close to 1,000 structures per day on a server with one graphics processing unit. Coupled with Google Colaboratory, ColabFold becomes a free and accessible platform for protein folding. ColabFold is open-source software available at https://github.com/sokrypton/ColabFold and its novel environmental databases are available at https://colabfold.mmseqs.com. ColabFold is a free and accessible platform for protein folding that provides accelerated prediction of protein structures and complexes using AlphaFold2 or RoseTTAFold.
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