Rates of decline in regions of the visual field defined by frequency-domain optical coherence tomography in patients with RPGR-mediated X-linked retinitis pigmentosa.
Rates of decline in regions of the visual field defined by frequency-domain optical coherence tomography in patients with RPGR-mediated X-linked retinitis pigmentosa.
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DOI：
10.1016/j.ophtha.2014.11.005
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发表时间：
2015-04
期刊：
影响因子：
13.7
通讯作者：
Hood, Donald C.
中科院分区：
文献类型：
--
作者：
Birch, David G.;Locke, Kirsten G.;Felius, Joost;Klein, Martin;Wheaton, Dianna K. H.;Hoffman, Dennis R.;Hood, Donald C.
目的探讨频域光学相干层析成像（fdOCT）内段椭球区（EZ）边缘的过渡区是否比视野中其他位置的视野灵敏度年下降幅度更大。前瞻性、纵向、观察性研究。参与者：44例由therpgr基因突变引起的x连锁视网膜色素变性（XLRP）患者。方法连续4年每年获得静态视场（Humphrey 30-2; Carl Zeiss Meditec, Dublin， CA）。从第二年开始，每年使用海德堡Spectralis HRA + OCT（海德堡工程，海德堡，德国）获得fdOCT扫描。主要观察指标：与黄斑区和中周区相比，靠近视界边缘的视野下降率。结果EZ边缘内外的灵敏度分别以0.84 dB/年和0.92 dB/年的速率下降。相比之下，黄斑和中周的平均灵敏度分别下降了0.38和0.61 dB/年。结论每例XLRP患者的EZ边缘显示了相对健康和相对退化视网膜之间的过渡区。在过渡区，每年的敏感性丧失比视网膜的其他部位更快。
PurposeTo determine whether annual decline in visual field sensitivity is greater in the transition zone at the edge of the frequency-domain optical coherence tomography (fdOCT) inner segment ellipsoid zone (EZ) than at other locations in the visual field.DesignProspective, longitudinal, observational study.ParticipantsForty-four patients with X-linked retinitis pigmentosa (XLRP) resulting from a mutation in theRPGRgene.MethodsStatic perimetric fields (Humphrey 30-2; Carl Zeiss Meditec, Dublin, CA) were obtained annually for 4 years. Beginning with year 2, fdOCT scans were obtained annually with a Heidelberg Spectralis HRA + OCT (Heidelberg Engineering, Heidelberg, Germany).Main Outcome MeasuresThe rate of visual field decline at locations near the edge of the EZ compared with the rates for the macula and in the mid periphery.ResultsSensitivity just inside and outside the edge of the EZ declined at rates of 0.84 and 0.92 dB/year, respectively. By comparison, average sensitivity in the macula and mid periphery declined by 0.38 and 0.61 dB/year, respectively.ConclusionsThe edge of the EZ in each patient with XLRP indicates a transition zone between relatively healthy and relatively degenerate retina. The annual loss of sensitivity in the transition zone is more rapid than it is elsewhere in the retina.
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影响因子：
3.4
作者：
Kocaoglu OP;Lee S;Jonnal RS;Wang Q;Herde AE;Derby JC;Gao W;Miller DT
通讯作者：
Miller DT
X连锁性视网膜炎的患者外部段层进展的光谱域光学相干断层扫描测量。
影响因子：
8.1
作者：
Birch, David G.;Locke, Kirsten G.;Wen, Yuquan;Locke, Kelly I.;Hoffman, Dennis R.;Hood, Donald C.
通讯作者：
Hood, Donald C.
影响因子：
1.4
作者：
Seiple, W;Clemens, CJ;Holopigian, K
通讯作者：
Holopigian, K
影响因子：
4.4
作者：
Jacobson, Samuel G.;Aleman, Tomas S.;Kimberling, William J.
通讯作者：
Kimberling, William J.
影响因子：
4.4
作者：
Hood DC;Lin CE;Lazow MA;Locke KG;Zhang X;Birch DG
通讯作者：
Birch DG