Neonatal thyroid function after propylthiouracil therapy for maternal Graves' disease.
Neonatal thyroid function after propylthiouracil therapy for maternal Graves' disease.
复制标题
丙硫氧嘧啶治疗产妇格雷夫斯病后的新生儿甲状腺功能。
DOI：
10.1056/nejm198102263040907
复制
发表时间：
1981
期刊：
影响因子：
--
通讯作者：
CriglerJr,JF
中科院分区：
文献类型：
--
作者：
Cheron,RG;Kaplan,MM;Larsen,PR;Selenkow,HA;CriglerJr,JF
丙硫氧嘧啶（PTU）是治疗妊娠期甲状腺功能亢进症的主要药物。它抑制甲状腺激素合成、甲状腺素 (T.) 甲状腺外转化为 3, 5, 3'-三碘甲状腺原氨酸 (Ta)，以及激素非活性 T 代谢物 3, 3'5'-三碘甲状腺原氨酸 (rT,) 的脱碘降解，但 PTU 可穿过胎盘，并且在高剂量时 可能导致胎儿甲状腺肿和甲状腺功能减退症。低剂量的 PTU（每日 300 毫克或更少）被认为可以令人满意地控制母体甲状腺功能亢进症，而不会导致新生儿临床上明显的甲状腺功能障碍。在遇到一名患有胎儿甲状腺肿和甲状腺功能减退症的婴儿（指导病例）（母亲每天接受 400 毫克 PTU）后，作者对接受低剂量 PTU 治疗的甲状腺功能亢进母亲所生的婴儿进行了出生时、第 1 天和第 3 天甲状腺功能的前瞻性研究。这些婴儿虽然临床上甲状腺功能正常，但有轻度、暂时性甲状腺功能减退症的生化证据。11 名妇女在怀孕期间接受了甲状腺功能亢进格雷夫斯病治疗，使用了能够充分控制其甲状腺功能亢进的最小剂量的 PTU。七名女性还接受了甲状腺激素补充剂-tatjorn 的形式|乔特里克斯。 Elood 取自每个新生儿的脐带和脚后跟。研究期间出生的正常婴儿的四十份脐带血清样本作为同期对照。作者记录中的正常值提供了历史对照。指数案例从所有组计算中排除，值以平均 t SEM 的形式报告。足月时，母亲每天接受 100 至 200 毫克 PTU。孕妇的血清 T、TSH 和 rT 浓度正常，平均游离 T 指数为 6.8 = 1, 0（正常怀孕和非怀孕成人的平均值为 6.9）。未接受甲状腺激素补充剂的患者与接受甲状腺激素补充剂的患者之间的平均血清游离 T 指数没有显着差异，
Propylthiouracil (PTU) is a mainstay of medical treat-ment for hyperthyroidism during pregnancy. It inhibitS thyroid hormone synthesis, extrathyroidal conversion of thyroxine (T.) to 3, 5, 3'-triiodothyronine (Ta), and deiodinative degradation of the hormonally inactive T metab-olite 3, 3'5'-triiodothyronine (rT,), PTU Crosses the placenţa, however, and at high doses it may cause fetal goiter and hypothyroidism. Low doses of PTU (300 mg or less daily) are thought to afford satisfactory control of maternal hyperthyroidism without causing Clinically evi-dent thyroid dysfunction in the neonate. After encountering an infant with fetal goiter and hypothyroidism (index case)(the mother was receiving 400 mg of PTU daily), the authors initiated a prospective study of thyroid function at birth, at 1 day, and at 3 days in jnfants born to hyperthyroid mothers who had been treated with low doses of PTU. These infants, although clinically euthyroid, had biochemical evidence of mild, transjent hypothyroidiSm.Eleven women were treated for hyperthyroid Graves' disease during pregnancy with the smallest dose of PTU that could control their hyperthyroidism adequately. Seven women also received thyroid hormone supplemen-tatjorn in the form of| jotrix. Elood was taken from the umbilical cord and heel of each neonate. Forty cord serum samples from normal infants born during the study period served as concurrent controls. Normal values from the authors' records provided historical Controls. The index CaSe WaS eXCluCled frOm all grOup CalCulatiOnS, ValueS are repOrted aS the mean-t SEM, At term, the mothers were receiving 1 OO to 200 mg of PTU daily. Their serum T,, TSH, and rT, concentrations were normal for pregnant women, as was the mean free-T, index of 6.8= 1, 0 (mean in normal pregnant and nonpregnant adults, 6.9). There was no significant differenCe in mean Serum free-T, index between patientS who were not receiving thyroid hormone supplements and those who were,
登录
查看更多内容
0 至 130 小时健康婴儿血清中反向三碘甲状腺原氨酸水平的波动。
影响因子：
5.8
作者：
B. Bernard;T. H. Oddie;A. Klein;D. Fisher
通讯作者：
D. Fisher
人类足月妊娠中母体和胎儿循环之间的甲状腺激素关系：一项针对甲状腺功能正常和异常患者的研究。
影响因子：
9.8
作者：
N. I. Robin;S. Refetoff;R. Gleason;H. Selenkow
通讯作者：
H. Selenkow
正常新生儿血清甲状腺激素水平的波动受到抑制。
影响因子：
5.8
作者：
T. H. Oddie;B. Bernard;M. Presley;A. Klein;D. Fisher
通讯作者：
D. Fisher
甲状腺功能亢进症中的三碘甲状腺原氨酸和甲状腺素。
影响因子：
15.9
作者：
J. Abuid;P. Larsen
通讯作者：
P. Larsen
血清 3,3,5-三碘甲状腺原氨酸（反向 T3）浓度的变化随甲状腺激素分泌和代谢的改变而变化。
影响因子：
5.8
作者：
Michael M. Kaplan;M. Schimmel;R. D. Utiger
通讯作者：
R. D. Utiger