Dispositional mindfulness and depressive symptomatology: correlations with limbic and self-referential neural activity during rest.
Dispositional mindfulness and depressive symptomatology: correlations with limbic and self-referential neural activity during rest.
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DOI：
10.1037/a0018312
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发表时间：
2010-02
期刊：
影响因子：
4.2
通讯作者：
Lieberman, Matthew D.
中科院分区：
文献类型：
--
作者：
Way, Baldwin M.;Creswell, J. David;Eisenberger, Naomi I.;Lieberman, Matthew D.
为了更好地理解正念和抑郁之间的关系，我们研究了正常的年轻人（n=27），他们完成了气质正念和抑郁情绪的测量，然后与：a）休息：相对于简单的目标导向任务，被动观看固定十字架时的休息神经活动（形状匹配）;和B）反应性：相对于相同的形状匹配任务，在观看负面情绪面部期间的神经反应性。气质正念与自我参照加工区的静息活动呈负相关，而抑郁性正念与类似区域的静息活动呈正相关。此外，气质正念与杏仁核的静息活动呈负相关，双侧，而抑郁性抑郁症与右侧杏仁核的活动呈正相关。同样，当观察情绪化的面孔时，杏仁核的反应与抑郁症呈正相关，与气质正念呈负相关，这种效应主要归因于静息活动的差异。这些研究结果表明，正念与内在神经活动有关，杏仁核静息活动的变化可能是一种潜在的机制，通过这种机制，基于正念的抑郁症治疗可以引起治疗效果的改善。
To better understand the relationship between mindfulness and depression, we studied normal young adults (n=27) who completed measures of dispositional mindfulness and depressive symptomatology, which were then correlated with: a) Rest: resting neural activity during passive viewing of a fixation cross, relative to a simple goal-directed task (shape-matching); and b) Reactivity: neural reactivity during viewing of negative emotional faces, relative to the same shape-matching task. Dispositional mindfulness was negatively correlated with resting activity in self-referential processing areas, while depressive symptomatology was positively correlated with resting activity in similar areas. In addition, dispositional mindfulness was negatively correlated with resting activity in the amygdala, bilaterally, while depressive symptomatology was positively correlated with activity in the right amygdala. Similarly, when viewing emotional faces, amygdala reactivity was positively correlated with depressive symptomatology and negatively correlated with dispositional mindfulness, an effect that was largely attributable to differences in resting activity. These findings indicate that mindfulness is associated with intrinsic neural activity and that changes in resting amygdala activity could be a potential mechanism by which mindfulness-based depression treatments elicit therapeutic improvement.
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影响因子：
1.7
作者：
Abercrombie, HC;Schaefer, SM;Davidson, RJ
通讯作者：
Davidson, RJ
DOI：
10.1073/pnas.162356599
发表时间：
2002-08-06
影响因子：
11.1
作者：
Canli, T;Desmond, JE;Gabrieli, JDE
通讯作者：
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影响因子：
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作者：
Anderson, AK;Phelps, EA
通讯作者：
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影响因子：
3.1
作者：
Drevets, Wayne C.;Price, Joseph L.;Furey, Maura L.
通讯作者：
Furey, Maura L.
DOI：
10.1196/annals.1440.011
发表时间：
2008-01-01
期刊：
YEAR IN COGNITIVE NEUROSCIENCE 2008
影响因子：
--
作者：
Buckner, Randy L.;Andrews-Hanna, Jessica R.;Schacter, Daniel L.
通讯作者：
Schacter, Daniel L.