Corticospinal Excitability in Children with Congenital Hemiparesis.
Corticospinal Excitability in Children with Congenital Hemiparesis.
复制标题
先天性偏瘫儿童的皮质脊髓兴奋性。
DOI：
10.3390/brainsci6040049
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发表时间：
2016-10-20
期刊：
影响因子：
3.3
通讯作者：
Gillick BT
中科院分区：
文献类型：
--
作者：
Chen CY;Rich TL;Cassidy JM;Gillick BT
经颅磁刺激（TMS）可用作评估或干预，以评估或影响常由围产期卒中引起的轻偏瘫型脑性瘫痪（CP）儿童的大脑活动。本通讯报告分析了来自两项临床试验的数据，这些试验使用经颅磁刺激来评估轻偏瘫CP儿童和年轻人的皮质脊髓兴奋性。该通信的结果显示，与病变半球相比，在非病变半球上发现运动诱发电位（MEP）的概率更高（p = 0.005）。非病变半球的静息运动阈值（RMT）低于病变半球（p = 0.013）。年龄与RMT之间存在显著负相关（rs =-0.65，p = 0.003）。本通讯提供了有关MEP反应，运动阈值（MT）和TMS评估期间与年龄的关联，在偏瘫CP儿童的信息。这些发现有助于未来儿科神经可塑性和神经调节研究的发展，以影响围产期卒中后的运动功能和恢复。
Transcranial magnetic stimulation (TMS) can be used as an assessment or intervention to evaluate or influence brain activity in children with hemiparetic cerebral palsy (CP) commonly caused by perinatal stroke. This communication report analyzed data from two clinical trials using TMS to assess corticospinal excitability in children and young adults with hemiparetic CP. The results of this communication revealed a higher probability of finding a motor evoked potential (MEP) on the non-lesioned hemisphere compared to the lesioned hemisphere (p = 0.005). The resting motor threshold (RMT) was lower on the non-lesioned hemisphere than the lesioned hemisphere (p = 0.013). There was a significantly negative correlation between age and RMT (rs = −0.65, p = 0.003). This communication provides information regarding MEP responses, motor thresholds (MTs) and the association with age during TMS assessment in children with hemiparetic CP. Such findings contribute to the development of future pediatric studies in neuroplasticity and neuromodulation to influence motor function and recovery after perinatal stroke.
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