Evaluation of Carbon Ion Radiation-Induced Trismus in Head and Neck Tumors Using Dose-Volume Histograms.
Evaluation of Carbon Ion Radiation-Induced Trismus in Head and Neck Tumors Using Dose-Volume Histograms.
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使用剂量体积直方图评价头颈部肿瘤中碳离子辐射诱导的牙关紧闭。
DOI：
10.3390/cancers12113116
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发表时间：
2020-10-25
期刊：
影响因子：
5.2
通讯作者：
Ohno T
中科院分区：
文献类型：
--
作者：
Musha A;Shimada H;Kubo N;Kawamura H;Okano N;Miyasaka Y;Sato H;Shirai K;Saitoh JI;Yokoo S;Chikamatsu K;Ohno T
接受碳离子放射治疗（C离子RT）治疗颞下颌关节附近肿瘤的患者可能会出现牙关紧闭，这是一种以下颌开口减少为特征的疾病。然而，碳离子剂量与牙关紧闭发作之间的关系尚不清楚。因此，我们进行了一项前瞻性观察性研究的亚组分析，以了解碳离子剂量与牙关紧闭发生的关系。在纳入研究的35例患者中，6例发生2级牙关紧闭，中位发病时间为12个月。受影响的肌肉包括咀嚼肌和冠状突。我们的研究结果表明，更好的治疗计划，如剂量优化，以尽量减少与C-离子RT相关的肌肉相关的不良反应的发生。碳离子放射治疗（C-离子RT）提供了一个高度局部化的能量沉积，可以增加辐射剂量的肿瘤，同时尽量减少照射相邻的正常组织。对于位于颞下颌关节附近的肿瘤，可能会发生C离子RT诱导的牙关紧闭。然而，碳离子剂量和牙关紧闭发作之间的关系尚不清楚。在这项前瞻性观察性研究中，我们使用剂量-体积直方图评估了2010年至2014年间在头颈部接受C离子RT的35例患者的牙关紧闭/碳离子剂量关系。根据不良事件通用术语标准（版本4.0）对患者的牙关紧闭进行评价。所有患者均接受57.6或64.0戈伊（相对生物学有效性（RBE））分16次治疗，中位随访时间为57个月。在6例患者中观察到2级牙关紧闭。中位发病时间为12个月。在最大辐射剂量下，所有咀嚼肌和冠状突，特别是咬肌，均存在显著差异（p = 0.003）。咬肌和喙突的轮廓需要不同的治疗计划。冠状突的最大辐射剂量可以作为治疗计划的指导方针，考虑到C离子RT中轮廓的容易性。
Patients who receive carbon ion radiotherapy (C-ion RT) for tumors near the temporomandibular joint are likely to experience trismus, a condition characterized by reduced jaw opening. However, the relationship between the dose of carbon ion and the onset of trismus remains unclear. Therefore, we conducted a subgroup analysis of a prospective observational study to understand the relationship between the dose of carbon ion and the occurrence of trismus. Of 35 patients included in the study, six developed grade 2 trismus, and the median onset time was 12 months. The affected muscles included masticatory muscles and the coronoid process. Our findings suggest better treatment planning, such as dose optimization, to minimize the occurrence of muscle-related adverse effects associated with C-ion RT. Carbon ion radiotherapy (C-ion RT) provides a highly localized deposition of energy that can increase radiation doses to tumors while minimizing irradiation of adjacent normal tissues. For tumors located near the temporomandibular joint, C-ion RT-induced trismus may occur. However, the relationship between the carbon ion dose and the onset of trismus is unclear. In this prospective observational study, we assessed the trismus/carbon ion dose relationship using dose−volume histograms in 35 patients who received C-ion RT in their head and neck regions between 2010 and 2014. Trismus was evaluated in patients according to the Common Terminology Criteria for Adverse Events, version 4.0. All patients were treated with 57.6 or 64.0 Gy (relative biological effectiveness (RBE)) in 16 fractions, and the median follow-up time was 57 months. Grade 2 trismus was observed in six patients. The median onset time was 12 months. At maximum radiation doses, all masticatory muscles and coronoid processes, particularly the masseter muscle, were significantly different (p = 0.003). The contouring of the masseter muscle and coronoid process requires different treatment planning. The maximum radiation doses of the coronoid process can be proposed as a guideline for treatment planning, considering the ease of contouring in C-ion RT.
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影响因子：
8.8
作者：
Zeng, L.;Tian, Y-M;Sun, X-M;Chen, C-Y;Han, F.;Xiao, W-W;Deng, X-W;Lu, T-X
通讯作者：
Lu, T-X
DOI：
10.1186/s13014-015-0414-8
发表时间：
2015-05-06
期刊：
Radiation oncology (London, England)
影响因子：
--
作者：
Jensen AD;Uhl M;Chaudhri N;Herfarth KK;Debus J;Roeder F
通讯作者：
Roeder F
影响因子：
5.7
作者：
Shirai K;Saitoh JI;Musha A;Abe T;Kobayashi D;Takahashi T;Tamaki T;Kawamura H;Takayasu Y;Shino M;Toyoda M;Takahashi K;Hirato J;Yokoo S;Chikamatsu K;Ohno T;Nakano T;Working Group on Head and Neck Tumors
通讯作者：
Working Group on Head and Neck Tumors
影响因子：
3.1
作者：
van der Geer, S. Joyce;Kamstra, Jolanda I.;Dijkstra, Pieter U.
通讯作者：
Dijkstra, Pieter U.
DOI：
10.1016/j.ijom.2014.12.009
发表时间：
2015-03-01
影响因子：
2.4
作者：
Steiner, F.;Evans, J.;Tan, S. T.
通讯作者：
Tan, S. T.