The interrelationship of dopamine D2-like receptor availability in striatal and extrastriatal brain regions in healthy humans: a principal component analysis of [18F]fallypride binding.
The interrelationship of dopamine D2-like receptor availability in striatal and extrastriatal brain regions in healthy humans: a principal component analysis of [18F]fallypride binding.
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DOI：
10.1016/j.neuroimage.2010.02.006
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发表时间：
2010-05-15
期刊：
影响因子：
5.7
通讯作者：
Kessler, Robert M.
中科院分区：
文献类型：
--
作者：
Zald, David H.;Woodward, Neil D.;Cowan, Ronald L.;Riccardi, Patrizia;Ansari, M. Sib;Baldwin, Ronald M.;Cowan, Ronald L.;Smith, Clarence E.;Hakyemez, Helene;Li, Rui;Kessler, Robert M.
Individual differences in dopamine D2-like receptor availability arise across all brain regions expressing D2-like receptors. However, the inter-relationships in receptor availability across brain regions are poorly understood. To address this issue, we examined the relationship between D2-like binding potential (BPND) across striatal and extrastriatal regions in a sample of healthy participants. PET imaging was performed with the high affinity D2/D3 ligand [18F]fallypride in 45 participants. BPND images were submitted to voxel-wise principal components analysis to determine the pattern of associations across brain regions. Individual differences in D2-like BPND were explained by three distinguishable components. A single component explained almost all of the variance within the striatum, indicating that individual differences in receptor availability vary in a homogenous manner across the caudate, putamen, and ventral striatum. Cortical BPND was only modestly related to striatal BPND, and mostly loaded on a distinct component. After controlling for the general level of cortical D2-like BPND, an inverse relationship emerged between receptor availability in the striatum and the ventral temporal and ventromedial frontal cortices, suggesting possible cross-regulation of D2-like receptors in these regions. The analysis additionally revealed evidence of: 1) a distinct component involving the midbrain and limbic areas; 2) a dissociation between BPND in the medial and lateral temporal regions; and 3) a dissociation between BPND in the medial/midline and lateral thalamus. In summary, individual differences in D2-like receptor availability reflect several distinct patterns. This conclusion has significant implications for neuropsychiatric models that posit global or regionally specific relationships between dopaminergic tone and behavior.
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影响因子：
4.2
作者：
Kaasinen, V;Vilkman, H;Rinne, JO
通讯作者：
Rinne, JO
DOI：
10.1097/00004647-199601000-00005
发表时间：
1996-01-01
影响因子：
6.3
作者：
Lammertsma, AA;Bench, CJ;Frackowiak, RSJ
通讯作者：
Frackowiak, RSJ
DOI：
10.1073/pnas.95.13.7731
发表时间：
1998-06-23
影响因子：
11.1
作者：
Khan, ZU;Mrzljak, L;Goldman-Rakic, PS
通讯作者：
Goldman-Rakic, PS
影响因子：
2.5
作者：
Lewis, DA;Melchitzky, DS;Sampson, A
通讯作者：
Sampson, A
影响因子：
7.6
作者：
Gurevich, EV;Joyce, JN
通讯作者：
Joyce, JN