Household mold, pesticide use, and childhood asthma: A nationwide study in the U.S.
Household mold, pesticide use, and childhood asthma: A nationwide study in the U.S.
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DOI：
10.1016/j.ijheh.2021.113694
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发表时间：
2021-04
影响因子：
6
通讯作者：
Zhu Y
中科院分区：
文献类型：
--
作者：
Xiao S;Ngo AL;Mendola P;Bates MN;Barcellos AL;Ferrara A;Zhu Y
为了调查家庭霉菌和农药使用与儿童哮喘风险之间的关联，并研究美国全国范围内儿童性别对儿童性别的潜在影响，全国代表性数据取自 2017 年和 2018 年全国儿童健康横断面调查。通过向主要护理人员发放标准调查问卷来评估过去 12 个月的家庭霉菌和农药暴露情况以及医生诊断的儿童哮喘。使用多变量逻辑回归模型来计算当前哮喘的调整优势比 (aOR)，并调整儿童、护理人员和家庭协变量。我们还研究了儿童性别对潜在影响的影响。抽样权重考虑了复杂的调查设计。 2017-2018 年，在 41,423 名美国儿童中，家庭接触霉菌的儿童当前哮喘的加权患病率为 10.8%，而未接触霉菌的儿童为 7.2%（P <0.001）。在调整包括儿童肥胖在内的协变量后，与没有接触过家庭霉菌的儿童相比，接触过家庭霉菌的儿童当前患哮喘的几率高出 1.41 倍（95% CI：1.07，1.87）。家庭霉菌与当前哮喘之间的关联在男孩中很明显（aOR 1.57；95% CI：1.03–2.38），但在女孩中则不然（aOR 1.28；0.90–1.83；交互作用 P <0.001）。调整协变量后，没有观察到家庭杀虫剂使用与当前哮喘之间存在显着关联。我们的研究结果表明，家庭霉菌与儿童当前的哮喘有关，与包括儿童肥胖状况在内的其他主要危险因素无关。我们的研究结果可能会为针对减轻家庭霉菌的策略提供参考，将其作为解决儿童哮喘的重要室内环境因素。
To investigate the associations of household mold and pesticide use with risk of childhood asthma and examine the potential effect modification by child’s sex at a national level in the U.S. Nationally representative data were drawn from the cross-sectional 2017 and 2018 National Surveys of Children’s Health. Household mold and pesticide exposures during the past 12 months and physician-diagnosed childhood asthma were assessed by standard questionnaires administered to primary caregivers. Multivariable logistic regression models were used to calculate adjusted odds ratios (aOR) for current asthma, adjusting for child, caregiver, and household covariates. We also examined potential effect modification by child’s sex. Sampling weights accounted for the complex survey design. Among 41,423 U.S. children in 2017–2018, the weighted prevalence of current asthma was 10.8% in household mold-exposed children, compared with 7.2% in non-exposed children (P <0.001). After adjusting for covariates including child’s obesity, children with household mold exposure compared to those with no household mold exposure had a 1.41-fold (95% CI: 1.07, 1.87) higher odds of current asthma. Associations between household mold and current asthma were pronounced among boys (aOR 1.57; 95% CI: 1.03–2.38) but not girls (aOR 1.28; 0.90–1.83; P for interaction <0.001). No significant associations were observed between household pesticide use and current asthma, after adjusting for covariates. Our findings suggest that household mold is associated with current asthma among children, independent of other major risk factors including child’s obesity status. Our findings may inform strategies targeting mitigation of household mold as an important indoor environment factor to address childhood asthma.
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DOI：
10.1016/j.ijheh.2011.07.004
发表时间：
2011-12-01
影响因子：
6
作者：
Chen, Yang-Ching;Tsai, Ching-Hui;Lee, Yungling Leo
通讯作者：
Lee, Yungling Leo
影响因子：
3.5
作者：
Fletcher, Jason M.;Green, Jeremy C.;Neidell, Matthew J.
通讯作者：
Neidell, Matthew J.
影响因子：
5.8
作者：
Fisk, W. J.;Lei-Gomez, Q.;Mendell, M. J.
通讯作者：
Mendell, M. J.
影响因子：
6.1
作者：
Behbod, B.;Sordillo, J. E.;Gold, D. R.
通讯作者：
Gold, D. R.
DOI：
10.1513/pats.200908-083rm
发表时间：
2010-05-01
期刊：
Proceedings of the American Thoracic Society
影响因子：
--
作者：
Breysse, Patrick N;Diette, Gregory B;McCormack, Meredith C
通讯作者：
McCormack, Meredith C