Associations of Fat Mass and Fat Distribution With Bone Mineral Density in Non-Obese Postmenopausal Chinese Women Over 60 Years Old.
Associations of Fat Mass and Fat Distribution With Bone Mineral Density in Non-Obese Postmenopausal Chinese Women Over 60 Years Old.
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DOI：
10.3389/fendo.2022.829867
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发表时间：
2022
影响因子：
5.2
通讯作者：
Zhang Q
中科院分区：
文献类型：
--
作者：
Fan J;Jiang Y;Qiang J;Han B;Zhang Q
骨密度（BMD）的损失是更年期的主要并发症，这种损失与脂肪量（FM）密切相关。然而，绝经后妇女的FM、脂肪分布（FD）和骨密度之间的关系仍不完全清楚。因此，本研究旨在探讨60岁以上非肥胖绝经后妇女体内脂肪积累、FD和BMD之间的关系。这是一项对357名年龄在60.2至86.7岁之间的健康绝经后妇女的横断面分析。采用双能x线骨密度仪（DXA）测量所有受试者的总骨密度和局部骨密度以及脂肪相关参数，包括总FM、android和gynoid脂肪、体脂率（BF%）和总瘦质量（LM）。采用雄性与雌性脂肪比（AOI）评估FD。采用Pearson相关检验和多元回归分析探讨AOI、LM、FM和BMD之间的关系。在单变量分析中，LM和FM与总骨密度和区域骨密度呈正相关（均P < 0.01），而骨密度与AOI在除头部外的任何分析部位均无显著相关性。校正了年龄、身高和绝经后年数的多元线性回归模型显示，FM和BMD之间存在持续的独立正相关（标准β范围：0.141 ~ 0.343,P < 0.01）。FM和骨密度之间的关系不受LM调整的影响（标准β范围：0.132 - 0.258,P < 0.01），而AOI对大多数分析的骨骼部位（全身、髋部、股骨颈、手臂、腿部和头部）的骨密度有不利影响（标准β范围：- 0.093至- 0.232,P < 0.05）。这些结果不受用BF%代替FM的影响（标准β范围：- 0.100至- 0.232,P < 0.05）。在这个来自中国的60岁以上非肥胖绝经后妇女队列中，总FM与骨密度呈正相关，而AOI与骨密度负相关。因此，适当增加体重和控制中枢性肥胖的结合可能有益于绝经后妇女的整体骨骼健康。
Bone mineral density (BMD) loss is a major complication of menopause, and this loss is closely associated with Fat mass (FM). The relationship between FM, fat distribution (FD), and BMD in postmenopausal women, however, remains incompletely understood. The present study was thus developed to explore these associations between body fat accumulation, FD, and BMD among non-obese postmenopausal women over the age of 60. This was a cross-sectional analysis of 357 healthy postmenopausal women between the ages of 60.2 and 86.7 years. Dual-energy X-ray absorptiometry (DXA) was utilized to measure total and regional BMD as well as fat-related parameters including total FM, android and gynoid fat, body fat percentage (BF%), and total lean mass (LM) for all subjects. The android-to-gynoid fat ratio (AOI) was used to assess FD. Pearson’s correlation testing and multiple regression analyses were used to explore relationships among AOI, LM, FM, and BMD. Both LM and FM were positively correlated with total and regional BMD in univariate analysis (all P < 0.01), whereas BMD was not significantly associated with AOI in any analyzed site other than the head. Multivariate linear regression models corrected for age, height, and years post-menopause, revealed a sustained independent positive relationship between FM and BMD (standard β range: 0.141 – 0.343, P < 0.01). The relationship between FM and BMD was unaffected by adjustment for LM (standard β range: 0.132 – 0.258, P < 0.01), whereas AOI had an adverse impact on BMD at most analyzed skeletal sites (total body, hip, femoral neck, arm, leg, and head) (standard β range: −0.093 to −0.232, P < 0.05). These findings were unaffected by using BF% in place of FM (standard β range: −0.100 to −0.232, P < 0.05). In this cohort of non-obese postmenopausal women over the age of 60 from China, total FM was positively associated with BMD, while AOI was negatively correlated with BMD. As such, a combination of proper weight gain and the control of central obesity may benefit the overall bone health of women after menopause.
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DOI：
10.1097/gme.0b013e31823a40ba
发表时间：
2012-04-01
影响因子：
2.7
作者：
Cheng, Qun;Zhu, Ying Xiao;Zhu, Min Han
通讯作者：
Zhu, Min Han
影响因子：
9.3
作者：
Bouchi R;Nakano Y;Ohara N;Takeuchi T;Murakami M;Asakawa M;Sasahara Y;Numasawa M;Minami I;Izumiyama H;Hashimoto K;Yoshimoto T;Ogawa Y
通讯作者：
Ogawa Y
DOI：
10.2147/ijwh.s41884
发表时间：
2013
期刊：
International journal of women's health
影响因子：
--
作者：
Namwongprom S;Rojanasthien S;Mangklabruks A;Soontrapa S;Wongboontan C;Ongphiphadhanakul B
通讯作者：
Ongphiphadhanakul B
影响因子：
--
作者：
Ilesanmi-Oyelere BL;Coad J;Roy N;Kruger MC
通讯作者：
Kruger MC
影响因子：
4
作者：
Fu, X.;Ma, X.;Zhu, S.
通讯作者：
Zhu, S.