Method for the biomechanical analysis of aqueous veins and perilimbal sclera by three-dimensional photoacoustic imaging and strain field calculation.
Method for the biomechanical analysis of aqueous veins and perilimbal sclera by three-dimensional photoacoustic imaging and strain field calculation.
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DOI：
10.1038/s41598-021-01458-1
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发表时间：
2021-11-11
影响因子：
4.6
通讯作者：
Argento A
中科院分区：
文献类型：
--
作者：
Ni L;Riesterer J;Wang H;Berry L;Blackburn K;Chuang J;Kim W;Xu G;Moroi SE;Argento A
本文提出了一种基于眼房水静脉的生物软组织成像和应变计算方法。对水静脉-角膜缘周围巩膜组织复合体的生物力学研究的挑战是作为眼内压的函数的组织变形的分辨率和随后的应变计算（变形的归一化测量）。该方法涉及在进行非侵入性、光学分辨率光声显微镜检查期间用造影剂灌注眼睛。这种成像技术允许在静脉内壁上的跟踪点的三维位移测量，其用于有限元模型中以确定相应的应变。两个标准的应变测量方法的方法进行了验证。代表性的猪地球仪灌注实验，证明该方法的力量，以确定复杂的应变场的静脉依赖于眼内压以及静脉解剖结构。在这些情况下，观察到静脉在眼内压增加期间径向向外移动，并且具有显著的空间应变变化，这可能受到其分支模式的影响。据作者所知，这些是公开文献中唯一可用的定量、数据驱动的水静脉应变计算。
A method motivated by the eye’s aqueous veins is described for the imaging and strain calculation within soft biological tissues. A challenge to the investigation of the biomechanics of the aqueous vein—perilimbal sclera tissue complex is resolution of tissue deformations as a function of intraocular pressure and the subsequent calculation of strain (a normalized measure of deformation). The method involves perfusion of the eye with a contrast agent during conduction of non-invasive, optical resolution photoacoustic microscopy. This imaging technique permits three-dimensional displacement measurements of tracked points on the inner walls of the veins which are used in a finite element model to determine the corresponding strains. The methods are validated against two standard strain measurement methods. Representative porcine globe perfusion experiments are presented that demonstrate the power of the method to determine complex strain fields in the veins dependent on intraocular pressure as well as vein anatomy. In these cases, veins are observed to move radially outward during increases in intraocular pressure and to possess significant spatial strain variation, possibly influenced by their branching patterns. To the authors’ knowledge, these are the only such quantitative, data driven, calculations of the aqueous vein strains available in the open literature.
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影响因子：
3.7
作者：
Man X;Arroyo E;Dunbar M;Reed DM;Shah N;Kagemann L;Kim W;Moroi SE;Argento A
通讯作者：
Argento A
影响因子：
4.4
作者：
Francis, Andrew W.;Kagemann, Larry;Schuman, Joel S.
通讯作者：
Schuman, Joel S.
DOI：
10.1115/1.4006847
发表时间：
2012-06-01
影响因子：
1.7
作者：
Kim, Wonsuk;Argento, Alan;Mallett, Kaitlyn
通讯作者：
Mallett, Kaitlyn
影响因子：
3.4
作者：
Lari, David R.;Schultz, David S.;Wang, Aaron S.;Lee, On-Tat;Stewart, Jay M.
通讯作者：
Stewart, Jay M.
影响因子：
4.1
作者：
Li, Pengcheng;Butt, Anum;Park, Sung Chul
通讯作者：
Park, Sung Chul