Contributions of Luminance and Motion to Visual Escape and Habituation in Larval Zebrafish.
Contributions of Luminance and Motion to Visual Escape and Habituation in Larval Zebrafish.
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DOI：
10.3389/fncir.2021.748535
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发表时间：
2021
影响因子：
3.5
通讯作者：
Scott EK
中科院分区：
文献类型：
--
作者：
Mancienne T;Marquez-Legorreta E;Wilde M;Piber M;Favre-Bulle I;Vanwalleghem G;Scott EK
从昆虫到人类的动物都会对隐约出现的刺激做出视觉逃避行为的反应，如果反复出现织机而没有后果，这些反应就会习惯。虽然基本的视觉处理和运动通路参与这种行为已经描述，许多细微差别的捕食者知觉和感觉运动门控没有。在这里，我们已经进行了行为分析和全脑细胞分辨率钙成像在幼体斑马鱼，同时向他们提供视觉织机刺激或刺激，选择性地提供运动或调光性能的全织机刺激。行为上，我们发现，虽然重复织机刺激的反应习惯，没有这样的习惯发生时，重复的运动刺激（在亮度变化的情况下）。昏暗的刺激很少引起逃避反应，因此不能习惯。无论是重复的运动刺激，也没有重复的调光刺激习惯于随后的充分织机刺激的反应，这表明，充分织机所需的习惯化。我们的钙成像显示，运动敏感神经元在大脑中很丰富，暗敏感神经元也存在，但更罕见，对两种刺激（以及对全织机刺激）都有反应的神经元集中在顶盖中。神经元选择性充分织机刺激（但不是运动或调光）是不明显的。最后，我们探讨了运动或昏暗敏感神经元是否有特征性的反应曲线在适应全织机。基线反应和习惯率之间的这种功能联系可能表明在全脑习惯网络中的特定作用，但在我们的数据中没有发现这种关系。总的来说，我们的研究结果表明，虽然运动和昏暗敏感神经元都有助于捕食者逃避行为，但在全脑视觉习惯网络或行为习惯中都没有发挥特定的作用。
Animals from insects to humans perform visual escape behavior in response to looming stimuli, and these responses habituate if looms are presented repeatedly without consequence. While the basic visual processing and motor pathways involved in this behavior have been described, many of the nuances of predator perception and sensorimotor gating have not. Here, we have performed both behavioral analyses and brain-wide cellular-resolution calcium imaging in larval zebrafish while presenting them with visual loom stimuli or stimuli that selectively deliver either the movement or the dimming properties of full loom stimuli. Behaviorally, we find that, while responses to repeated loom stimuli habituate, no such habituation occurs when repeated movement stimuli (in the absence of luminance changes) are presented. Dim stimuli seldom elicit escape responses, and therefore cannot habituate. Neither repeated movement stimuli nor repeated dimming stimuli habituate the responses to subsequent full loom stimuli, suggesting that full looms are required for habituation. Our calcium imaging reveals that motion-sensitive neurons are abundant in the brain, that dim-sensitive neurons are present but more rare, and that neurons responsive to both stimuli (and to full loom stimuli) are concentrated in the tectum. Neurons selective to full loom stimuli (but not to movement or dimming) were not evident. Finally, we explored whether movement- or dim-sensitive neurons have characteristic response profiles during habituation to full looms. Such functional links between baseline responsiveness and habituation rate could suggest a specific role in the brain-wide habituation network, but no such relationships were found in our data. Overall, our results suggest that, while both movement- and dim-sensitive neurons contribute to predator escape behavior, neither plays a specific role in brain-wide visual habituation networks or in behavioral habituation.
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影响因子：
16.2
作者：
Heap, Lucy A. L.;Vanwalleghem, Gilles;Scott, Ethan K.
通讯作者：
Scott, Ethan K.
DOI：
10.1002/neu.480080207
发表时间：
1977-01-01
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
EATON, RC;FARLEY, RD;SCHABTACH, E
通讯作者：
SCHABTACH, E
DOI：
10.1016/j.cub.2017.08.012
发表时间：
2017-09-25
期刊：
Current biology : CB
影响因子：
--
作者：
Bhattacharyya K;McLean DL;MacIver MA
通讯作者：
MacIver MA
影响因子：
5.3
作者：
Burgess, Harold A.;Granato, Michael
通讯作者：
Granato, Michael
影响因子：
16.2
作者：
Fernandes, Antonio M.;Mearns, Duncan S.;Baier, Herwig
通讯作者：
Baier, Herwig