Mesenteric arteries from stroke-prone spontaneously hypertensive rats exhibit an increase in nitric-oxide-dependent vasorelaxation.
Mesenteric arteries from stroke-prone spontaneously hypertensive rats exhibit an increase in nitric-oxide-dependent vasorelaxation.
复制标题
易发生中风的自发性高血压大鼠的肠系膜动脉表现出一氧化氮依赖性血管舒张作用的增加。
DOI：
10.1139/cjpp-2017-0477
复制
发表时间：
2018
影响因子：
2.1
通讯作者：
Giachini,FernandaR
中科院分区：
文献类型：
--
作者：
Wynne,BrandiM;Labazi,Hicham;Lima,VictorV;Carneiro,FernandoS;Webb,RClinton;Tostes,RitaC;Giachini,FernandaR
The endothelium is crucial for the maintenance of vascular tone by releasing several vasoactive substances, including nitric oxide (NO). Systemic mean arterial pressure is primarily regulated by the resistance vasculature, which has been shown to exhibit increased vascular reactivity, and decreased vasorelaxation during hypertension. Here, we aimed to determine the mechanism for mesenteric artery vasorelaxation of the stroke-prone spontaneously hypertensive rat (SHRSP). We hypothesized that endothelial NO synthase (eNOS) is upregulated in SHRSP vessels, increasing NO production to compensate for the endothelial dysfunction. Concentration–response curves to acetylcholine (ACh) were performed in second-order mesenteric arteries; we observed decreased relaxation responses to ACh (maximum effect elicited by the agonist) as compared with Wistar-Kyoto (WKY) controls. Vessels from SHRSP incubated withNω-nitro-l-arginine methyl ester and (or) indomethacin exhibited decreased ACh-mediated relaxation, suggesting a primary role for NO-dependent relaxation. Vessels from SHRSP exhibited a significantly decreased relaxation response with inducible NO synthase (iNOS) inhibition, as compared with WKY vessels. Western blot analysis showed increased total phosphorylated NF-κB, and phosphorylated and total eNOS in SHRSP vessels. Overall, these data suggest a compensatory role for NO by increased eNOS activation. Moreover, we believe that iNOS, although increasing NO bioavailability to compensate for decreased relaxation, leads to a cycle of further endothelial dysfunction in SHRSP mesenteric arteries.
登录
查看更多内容
选择性抑制抑制性 kappa B 激酶-β 消除脂多糖刺激的大鼠主动脉平滑肌细胞中一氧化氮合酶的诱导
影响因子：
7.3
作者：
A. B. Gómez;C. MacKenzie;A. Paul;R. Plevin
通讯作者：
R. Plevin
影响因子：
3.5
作者：
Dubois, G
通讯作者：
Dubois, G
我们如何学会说“不”
DOI：
--
发表时间：
2009
期刊：
Arteriosclerosis, Thrombosis and Vascular Biology
影响因子：
--
作者：
P. Vanhoutte
通讯作者：
P. Vanhoutte
IL-1β 增强自发性高血压大鼠主动脉中一氧化氮的产生。
影响因子：
3.2
作者：
Junquero,DC;Schini,VB;Scott-Burden,T;Vanhoutte,PM
通讯作者：
Vanhoutte,PM
DOI：
10.1006/bbrc.1993.1871
发表时间：
1993-07-30
影响因子：
3.1
作者：
MALINSKI, T;KAPTURCZAK, M;BOHR, D
通讯作者：
BOHR, D