Dual and mutual interaction between microbiota and viral infections: a possible treat for COVID-19.
Dual and mutual interaction between microbiota and viral infections: a possible treat for COVID-19.
复制标题
DOI：
10.1186/s12934-020-01483-1
复制
发表时间：
2020-11-26
影响因子：
6.4
通讯作者：
Haddad Kashani H
中科院分区：
文献类型：
--
作者：
Baghbani T;Nikzad H;Azadbakht J;Izadpanah F;Haddad Kashani H
所有人类和其他哺乳动物物种都被某些类型的微生物定居，如细菌、古生菌、单细胞真核生物如真菌和原生动物、多细胞真核生物如蠕虫和病毒，这些微生物统称为微生物区系。这些微生物之间有多种不同类型的相互作用。大量证据表明，它们可以调节免疫和消化系统，还在各种疾病中发挥作用，如精神疾病、心血管疾病、代谢疾病和一些皮肤病。此外，他们还参与了一些当前的健康问题，如糖尿病、肥胖症、癌症和感染。病毒感染是最常见和最有问题的医疗保健问题之一，特别是近年来，像SARS和新冠肺炎这样的大流行病给世界造成了大量的经济和物质损失。有大量研究微生物区系与传染病之间相互作用的文章。我们把重点放在微生物区系对病毒感染的刺激到抑制作用上，希望找到一种解决方案来克服目前的大流行。然后，我们从机械上综述了微生物区系和益生菌对大多数病毒的影响。但与以前专注于肠道微生物区系和感染的研究不同，我们的重点是呼吸系统的微生物区系和呼吸道病毒感染，记住呼吸系统是病毒的适当进入场所和栖息地，感染可导致无症状、轻度、自限性、严重甚至致命的感染。最后，我们过度概括了微生物区系对新冠肺炎感染的影响。此外，我们还对微生物区系对冠状病毒的影响进行了综述，并提出了一些新的治疗措施。
All of humans and other mammalian species are colonized by some types of microorganisms such as bacteria, archaea, unicellular eukaryotes like fungi and protozoa, multicellular eukaryotes like helminths, and viruses, which in whole are called microbiota. These microorganisms have multiple different types of interaction with each other. A plethora of evidence suggests that they can regulate immune and digestive systems and also play roles in various diseases, such as mental, cardiovascular, metabolic and some skin diseases. In addition, they take-part in some current health problems like diabetes mellitus, obesity, cancers and infections. Viral infection is one of the most common and problematic health care issues, particularly in recent years that pandemics like SARS and COVID-19 caused a lot of financial and physical damage to the world. There are plenty of articles investigating the interaction between microbiota and infectious diseases. We focused on stimulatory to suppressive effects of microbiota on viral infections, hoping to find a solution to overcome this current pandemic. Then we reviewed mechanistically the effects of both microbiota and probiotics on most of the viruses. But unlike previous studies which concentrated on intestinal microbiota and infection, our focus is on respiratory system’s microbiota and respiratory viral infection, bearing in mind that respiratory system is a proper entry site and residence for viruses, and whereby infection, can lead to asymptomatic, mild, self-limiting, severe or even fatal infection. Finally, we overgeneralize the effects of microbiota on COVID-19 infection. In addition, we reviewed the articles about effects of the microbiota on coronaviruses and suggest some new therapeutic measures.
登录
查看更多内容
DOI：
10.1038/nri3535
发表时间：
2013-11
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
4
作者：
Chang PV
通讯作者：
Chang PV
影响因子：
3.8
作者：
Audsley, Michelle D.;Ye, Yixin H.;McGraw, Elizabeth A.
通讯作者：
McGraw, Elizabeth A.
影响因子：
6.7
作者：
Berger AK;Yi H;Kearns DB;Mainou BA
通讯作者：
Mainou BA
影响因子：
3.7
作者：
Cardemil, Cristina V.;O'Leary, Sean T.;Hall, Aron J.
通讯作者：
Hall, Aron J.