Chemical Mechanisms of Colonization Resistance by the Gut Microbial Metabolome.
Chemical Mechanisms of Colonization Resistance by the Gut Microbial Metabolome.
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肠道微生物代谢组的定植抗性化学机制。
DOI：
10.1021/acschembio.9b00813
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发表时间：
2020-05-15
影响因子：
4
通讯作者：
Chang PV
中科院分区：
文献类型：
--
作者：
Chang PV
肠道微生物群是居住在肠道内的100万亿个微生物的集合，在调节宿主生理方面起着重要作用。肠道菌群的一个公认的功能是定植抗性或微生物集体保护宿主免受肠道病原体侵害的能力。尽管有证据表明这些微生物可能胜过某些病原体，但仍然缺乏对这种竞争排斥的机制理解。近年来，人们对肠道微生物群产生的小分子代谢物以及这些分子如何调节宿主-病原体相互作用产生了极大的兴趣。在这篇综述中，我们简要总结了这些发现，重点介绍了介导这一重要过程的几类代谢物。了解肠道中这些宿主-微生物的相互作用可能会导致鉴定出潜在的候选物，用于开发受肠道微生物群影响的许多传染病的预防和治疗方法。
The gut microbiome, the collection of 100 trillion microorganisms that resides in the intestinal lumen, plays major roles in modulating host physiology. One well-established function of the gut microbiota is that of colonization resistance or the ability of the microbial collective to protect the host against enteric pathogens. Although evidence suggests that these microbes may outcompete some pathogens, there remains a lack of mechanistic understanding that underlies this competitive exclusion. In recent years, there has been great interest in small-molecule metabolites that are produced by the gut microbiota and in understanding how these molecules regulate host–pathogen interactions. In this review, we briefly summarize these findings by focusing on several classes of metabolites that mediate this important process. Understanding these host–microbe interactions in the gut may lead to identification of potential candidates for the development of prophylactics and therapeutics for many infectious diseases that are impacted by the gut microbiome.
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DOI：
10.1038/nri3535
发表时间：
2013-11
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
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影响因子：
32.4
作者：
Dorrestein PC;Mazmanian SK;Knight R
通讯作者：
Knight R
DOI：
10.1126/science.aam9949
发表时间：
2017-08-11
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Byndloss MX;Olsan EE;Rivera-Chávez F;Tiffany CR;Cevallos SA;Lokken KL;Torres TP;Byndloss AJ;Faber F;Gao Y;Litvak Y;Lopez CA;Xu G;Napoli E;Giulivi C;Tsolis RM;Revzin A;Lebrilla CB;Bäumler AJ
通讯作者：
Bäumler AJ
影响因子：
3.3
作者：
Alva-Murillo, Nayeli;Ochoa-Zarzosa, Alejandra;Lopez-Meza, Joel E.
通讯作者：
Lopez-Meza, Joel E.
影响因子：
64.8
作者：
Fukuda, Shinji;Toh, Hidehiro;Ohno, Hiroshi
通讯作者：
Ohno, Hiroshi