Association between Metabolic Syndrome and Cognitive Impairment after Acute Ischemic Stroke: A Cross-Sectional Study in a Chinese Population.
Association between Metabolic Syndrome and Cognitive Impairment after Acute Ischemic Stroke: A Cross-Sectional Study in a Chinese Population.
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代谢综合征与急性缺血性中风后认知障碍之间的关联：中国人群的横断面研究
DOI：
10.1371/journal.pone.0167327
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Zhou YY
中科院分区：
文献类型：
--
作者：
Li P;Quan W;Lu D;Wang Y;Zhang HH;Liu S;Jiang RC;Zhou YY
背景与目的代谢综合征是许多血管疾病的危险因素，与血管认知障碍有关。本研究的目的是探讨蛋氨酸及其单独成分与急性卒中患者认知功能障碍和神经功能障碍的风险之间的关系。方法对天津市中国北部地区840例患者进行横断面研究，年龄53~89岁。认知功能采用蒙特利尔认知评估(MoCA)和简易智力状态检查进行评估。使用神经精神病学问卷对神经精神病学行为进行评估。采用汉密尔顿抑郁量表评定患者的情绪状态，采用美国国立卫生研究院卒中评定量表、Barthel指数和日常生活活动能力量表评定患者的神经运动功能。隔夜禁食后，取血样测定生化指标。结果蛋氨酸及其各组分与MoCA评分密切相关。METS患者炎症水平高，认知障碍的优势比(OR)增加3.542倍[95%可信区间(CI)：1.972-6.361]。在METS的个体成分中，中心性肥胖(OR 3.039；95%CI：1.839-5.023)、高空腹血糖(OR 1.915；95%CI：1.016-3.607)和2型糖尿病(OR 2.241；95%CI：1.630-3.081)与认知障碍的发生率增加相关。在不同的神经学领域观察到一致和显著的恶化，随着甲硫氨酸成分的增加。结论甲硫氨酸与中国急性卒中患者的认知功能、神经运动功能障碍和神经心理症状有关。
Background and Objectives Metabolic syndrome (MetS), a risk factor for many vascular conditions, is associated with vascular cognitive disorders. The objective of the present study was to explore the associations of MetS and its individual components with the risks of cognitive impairment and neurological dysfunction in patients after acute stroke. Methods This cross-sectional study enrolled 840 patients ranging in age from 53 to 89 years from the Tianjin area of North China. Cognitive function was evaluated using the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination. Neuropsychiatric behavior was assessed using the Neuropsychiatric Inventory Questionnaire. Emotional state was examined according to the Hamilton Depression Rating Scale, and neuromotor function was evaluated using the National Institutes of Health Stroke Scale, Barthel index, and the Activity of Daily Living test. After overnight fasting, blood samples were obtained to measure biochemistry indicators. Results MetS and its individual components were closely correlated with MoCA score. MetS patients had high levels of inflammation and a 3.542-fold increased odds ratio (OR) for cognitive impairment [95% confidence interval (CI): 1.972–6.361]. Of the individual MetS components, central obesity (OR 3.039; 95% CI: 1.839–5.023), high fasting plasma glucose (OR 1.915; 95% CI: 1.016–3.607), and type 2 diabetes (OR 2.241; 95% CI: 1.630–3.081) were associated with an increased incidence of cognitive impairment. Consistent and significant worsening in different neurological domains was observed with greater numbers of MetS components. Conclusions MetS was associated with worse cognitive function, neuromotor dysfunction, and neuropsychological symptoms among Chinese acute stroke patients.
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影响因子：
--
作者：
Azizi, Gholamreza;Navabi, Shadi S;Mirshafiey, Abbas
通讯作者：
Mirshafiey, Abbas
影响因子：
29
作者：
Kester, Maartje I.;Goos, Jeroen D. C.;van der Flier, Wiesje M.
通讯作者：
van der Flier, Wiesje M.
影响因子：
--
作者：
Razay, George;Vreugdenhil, Anthea;Wilcock, Gordon
通讯作者：
Wilcock, Gordon
影响因子：
2.1
作者：
Sachdev P;Kalaria R;O'Brien J;Skoog I;Alladi S;Black SE;Blacker D;Blazer DG;Chen C;Chui H;Ganguli M;Jellinger K;Jeste DV;Pasquier F;Paulsen J;Prins N;Rockwood K;Roman G;Scheltens P;Internationlal Society for Vascular Behavioral and Cognitive Disorders
通讯作者：
Internationlal Society for Vascular Behavioral and Cognitive Disorders
影响因子：
7.2
作者：
KATZMAN, R;ZHANG, MY;GRANT, I
通讯作者：
GRANT, I