Rational Design of High-Relaxivity Eu(II) -Based Contrast Agents for Magnetic Resonance Imaging of Low-Oxygen Environments.
Rational Design of High-Relaxivity Eu(II) -Based Contrast Agents for Magnetic Resonance Imaging of Low-Oxygen Environments.
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DOI：
10.1002/chem.202004450
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发表时间：
2021-02-10
期刊：
影响因子：
--
通讯作者：
Allen MJ
中科院分区：
文献类型：
--
作者：
Bailey MD;Jin GX;Carniato F;Botta M;Allen MJ
金属基磁共振造影剂为缺氧成像提供了一种很有前途的途径。基于EuII的造影剂具有独特的生物相关氧化还原偶，EuII/III，使这种金属在缺氧成像中与众不同。为此，我们研究了一种通过控制旋转动力学来增强euii基加密物在磁共振成像中的对比度增强能力的策略。合成了两种含euii的双金属隐体，以测试刚性与柔性耦合策略的有效性。灵活的二聚化策略导致每Eu离子（60 MHz, 298 K）对比度增强适度（114%）增加，但刚性连接策略导致对比度增强极好（186%）增加，尽管两种双金属配合物的分子质量较小。我们设想刚性连接策略在未来设计用于磁共振成像的强效euii型造影剂时是有用的。含euii配合物作为缺氧反应显像剂具有潜在的应用价值。研究了一种刚性的含euii的双金属隐状物作为磁共振成像的高效造影剂。核磁共振分散研究表明，该试剂比柔性双金属试剂和类似的小分子试剂具有更高的弛豫效率。
Metal-based contrast agents for magnetic resonance imaging present a promising avenue to image hypoxia. EuII-based contrast agents have a unique biologically relevant redox couple, EuII/III, that distinguishes this metal for use in hypoxia imaging. To that end, we investigated a strategy to enhance the contrast-enhancing capabilities of EuII-based cryptates in magnetic resonance imaging by controlling rotational dynamics. Two dimetallic, EuII-containing cryptates were synthesized to test the efficacy of rigid versus flexible coupling strategies. A flexible strategy to dimerization led to a modest (114%) increase in contrast enhancement per Eu ion (60 MHz, 298 K), but a rigid linking strategy led to an excellent (186%) increase in contrast enhancement despite having the smaller molecular mass of the two dimetallic complexes. We envision the rigid linking strategy to be useful in the future design of potent EuII-based contrast agents for magnetic resonance imaging. EuII-containing complexes have potential use as responsive imaging agents for hypoxia. A rigid, dimetallic EuII-containing cryptate was investigated as a high-efficiency contrast agent for magnetic resonance imaging. NMR dispersion studies indicate that this agent exhibits higher relaxometric efficiency than both a flexible dimetallic agent and analogous small-molecule agents.
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