Impairments of thalamic nuclei in idiopathic generalized epilepsy revealed by a study combining morphological and functional connectivity MRI.
Impairments of thalamic nuclei in idiopathic generalized epilepsy revealed by a study combining morphological and functional connectivity MRI.
复制标题
DOI：
10.1371/journal.pone.0039701
复制
发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Lu G
中科院分区：
文献类型：
--
作者：
Wang Z;Zhang Z;Jiao Q;Liao W;Chen G;Sun K;Shen L;Wang M;Li K;Liu Y;Lu G
神经影像学证据表明丘脑核团在特发性全身性癫痫(IGE)的发病过程中可能起不同的作用。本研究旨在证实IGE丘脑核团形态计量学和功能连接性的改变。52例以全身性强直-阵挛发作为特征的IGE患者和67例健康对照参与研究。获取三维高分辨率T1加权MRI数据用于体素形态计量(VBM)分析，获取静息状态血氧水平功能MRI数据用于功能连通性分析。通过VBM分析发现IGE患者双侧丘脑内侧背核(MDN)和枕核的灰质体积减小，作为进行功能连接分析的种子区。免疫球蛋白E内灰质体积减少，丘脑核团的功能连接出现不同的改变。植入MDN后，患者双侧眼眶额叶皮质、尾状核、壳核和杏仁核的连通性降低(经校正P<；0.05)。然而，在枕骨种植，患者没有发现明显的功能连通性改变(P<；0.05经校正)。用形态和功能连接性MRI方法检测IGE中丘脑核团的一些特异性损伤。这些发现可能有力地支持了丘脑皮质网络在IGE中的不同参与。
Neuroimaging evidence suggested that the thalamic nuclei may play different roles in the progress of idiopathic generalized epilepsy (IGE). This study aimed to demonstrate the alterations in morphometry and functional connectivity in the thalamic nuclei in IGE. Fifty-two patients with IGE characterized by generalized tonic-clonic seizures and 67 healthy controls were involved in the study. The three-dimensional high-resolution T1-weighted MRI data were acquired for voxel-based morphometry (VBM) analysis, and resting-state blood-oxygenation level functional MRI data were acquired for functional connectivity analysis. The thalamic nuclei of bilateral medial dorsal nucleus (MDN) and pulvinar, as detected with decreased gray matter volumes in patients with IGE through VBM analysis, were selected as seed regions for functional connectivity analysis. Different alteration patterns were found in functional connectivity of the thalamic nuclei with decreased gray matter volumes in IGE. Seeding at the MDN, decreased connectivity in the bilateral orbital frontal cortex, caudate nucleus, putamen and amygdala were found in the patients (P<0.05 with correction). However, seeding at the pulvinar, no significant alteration of functional connectivity was found in the patients (P<0.05 with correction). Some specific impairment of thalamic nuclei in IGE was identified using morphological and functional connectivity MRI approaches. These findings may strongly support the different involvement of the thalamocortical networks in IGE.
登录
查看更多内容
未接受抗精神病药物治疗的首发精神分裂症中脑缺陷与临床症状的关联：基于体素的优化形态测量和静息态功能连接研究
影响因子：
17.7
作者：
Lui, Su;Deng, Wei;Gong, Qiyong
通讯作者：
Gong, Qiyong
影响因子：
5.6
作者：
Moeller, Friederike;Maneshi, Mona;Gotman, Jean
通讯作者：
Gotman, Jean
DOI：
10.1523/jneurosci.5101-09.2010
发表时间：
2010-04-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bai X;Vestal M;Berman R;Negishi M;Spann M;Vega C;Desalvo M;Novotny EJ;Constable RT;Blumenfeld H
通讯作者：
Blumenfeld H
影响因子：
5.6
作者：
Berg, Anne T.;Berkovic, Samuel F.;Scheffer, Ingrid E.
通讯作者：
Scheffer, Ingrid E.
遗忘型轻度认知障碍患者的解剖和功能缺陷
影响因子：
3.7
作者：
Han Y;Lui S;Kuang W;Lang Q;Zou L;Jia J
通讯作者：
Jia J