Polymorphism in heme oxygenase-1 (HO-1) promoter is related to the risk of oral squamous cell carcinoma occurring on male areca chewers.
Polymorphism in heme oxygenase-1 (HO-1) promoter is related to the risk of oral squamous cell carcinoma occurring on male areca chewers.
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DOI：
10.1038/sj.bjc.6602186
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发表时间：
2004-10-18
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
咀嚼槟榔与亚洲人口腔鳞状细胞癌（OSCC）和口腔粘膜下纤维性变（OSF）的高发病率有关。血红素加氧酶-1（HO-1）是一种氧化反应蛋白，在细胞中起保护作用。HO-1基因启动子区的A（GT）n微卫星重复序列具有多态性，并调节基因转录水平。我们检测了83例对照、147例口腔鳞癌和71例口腔鳞状细胞癌的（GT）n重复序列的等位基因型频率。所有受试者均为男性槟榔咀嚼者。Logistic回归分析用于调整年龄混杂因素的比值比（OR）。(GT)n重复多态性分为短（S）、中（M）和长（L）等位基因。在OSCC患者中，L等位基因型相对于S等位基因型的校正OR为1.75。颊部鳞状细胞癌是槟榔咀嚼者最常见的口腔鳞状细胞癌。L等位基因提示BSCC的风险，调整OR为2.05，而M等位基因对非BSCC有保护作用，调整OR为0.49。HO-1基因启动子区较长的（GT）n重复等位基因与槟榔相关口腔鳞癌的发病风险相关，而较短的（GT）n重复等位基因可能对口腔鳞癌有保护作用。
Areca (betel) chewing is associated with the high incidence of oral squamous cell carcinoma (OSCC) and oral submucous fibrosis (OSF) in Asians. Heme oxygenase-1 (HO-1), encoding an oxidative response protein, plays protective roles in cells. A (GT)n microsatellite repeat in HO-1 promoter shows polymorphisms and modulates the level of gene transcription. We examined allelotypic frequencies of (GT)n repeats in 83 controls, 147 OSCC and 71 OSF. All subjects were male areca chewers. Logistic regression was used to adjust the age confounding for odds ratio (OR). (GT)n repeat polymorphism was classified into short (S), medium (M) and long (L) alleles. The adjusted OR in OSCC subjects carrying L allelotype relative to S allelotype was 1.75. Buccal squamous cell carcinoma (BSCC) is the most common OSCC subset in areca chewers. L allelotype implied the risk of BSCC with adjusted OR of 2.05, whereas M allelotype appeared protective for non-BSCC with adjusted OR of 0.49. Our findings indicated that longer (GT)n repeat allele in HO-1 promoter is associated with the risks of areca-related OSCC, while the shorter (GT)n repeat allele may have protective effects for OSCC.
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DOI：
10.1016/s0165-1218(96)90018-x
发表时间：
1996-01-01
期刊：
MUTATION RESEARCH-GENETIC TOXICOLOGY
影响因子：
--
作者：
Liu, TY;Chen, CL;Chi, CW
通讯作者：
Chi, CW
影响因子：
3.3
作者：
Ko, SY;Lin, SC;Liu, TY
通讯作者：
Liu, TY
影响因子：
3.3
作者：
Liu, CJ;Lee, YJ;Dang, CW
通讯作者：
Dang, CW
影响因子：
1.9
作者：
Lo, WL;Kao, SY;Chang, RCS
通讯作者：
Chang, RCS
影响因子：
3.3
作者：
Lin, SC;Chung, MY;Chang, KW
通讯作者：
Chang, KW