Adult Neurogenesis in the Drosophila Brain: The Evidence and the Void.
Adult Neurogenesis in the Drosophila Brain: The Evidence and the Void.
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DOI：
10.3390/ijms21186653
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发表时间：
2020-09-11
影响因子：
5.6
通讯作者：
Hidalgo A
中科院分区：
文献类型：
--
作者：
Li G;Hidalgo A
确定包括人类在内的动物的成年大脑中神经发生的存在和程度，将改变我们对大脑如何工作以及如何应对脑损伤和疾病的理解。获得令人信服、无可争议的实验证据通常具有挑战性。在这里，我们修改了果蝇中这个问题的状态。在成蝇羽化之前，形成中枢神经系统和大脑的发育神经母细胞通过细胞凋亡或细胞周期退出而被消除。尽管如此，越来越多的证据表明成人大脑中可以发生细胞增殖。这优先发生在但不限于关键时期。成体增殖细胞可以产生神经胶质细胞和神经元。成人的神经元活动、损伤和基因操作会增加胶质生成和神经发生的发生率以及细胞数量。最有可能的是，成人胶质细胞和神经发生促进大脑结构可塑性和稳态。然而，成人大脑有丝分裂的明确可视化仍然缺乏，并且难以捉摸的成人祖细胞尚未被识别。解决这些空白对于任何大脑的基本理解都很重要。鉴于其强大的遗传学，果蝇可以加快发现哺乳动物成体健康和患病大脑中的神经发生。
Establishing the existence and extent of neurogenesis in the adult brain throughout the animals including humans, would transform our understanding of how the brain works, and how to tackle brain damage and disease. Obtaining convincing, indisputable experimental evidence has generally been challenging. Here, we revise the state of this question in the fruit-fly Drosophila. The developmental neuroblasts that make the central nervous system and brain are eliminated, either through apoptosis or cell cycle exit, before the adult fly ecloses. Despite this, there is growing evidence that cell proliferation can take place in the adult brain. This occurs preferentially at, but not restricted to, a critical period. Adult proliferating cells can give rise to both glial cells and neurons. Neuronal activity, injury and genetic manipulation in the adult can increase the incidence of both gliogenesis and neurogenesis, and cell number. Most likely, adult glio- and neuro-genesis promote structural brain plasticity and homeostasis. However, a definitive visualisation of mitosis in the adult brain is still lacking, and the elusive adult progenitor cells are yet to be identified. Resolving these voids is important for the fundamental understanding of any brain. Given its powerful genetics, Drosophila can expedite discovery into mammalian adult neurogenesis in the healthy and diseased brain.
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影响因子：
11.8
作者：
Lai, Sen-Lin;Miller, Michael R.;Robinson, Kristin J.;Doe, Chris Q.
通讯作者：
Doe, Chris Q.
影响因子：
64.5
作者：
Davie K;Janssens J;Koldere D;De Waegeneer M;Pech U;Kreft Ł;Aibar S;Makhzami S;Christiaens V;Bravo González-Blas C;Poovathingal S;Hulselmans G;Spanier KI;Moerman T;Vanspauwen B;Geurs S;Voet T;Lammertyn J;Thienpont B;Liu S;Konstantinides N;Fiers M;Verstreken P;Aerts S
通讯作者：
Aerts S
影响因子：
64.5
作者：
Homem, Catarina C. F.;Steinmann, Victoria;Knoblich, Juergen A.
通讯作者：
Knoblich, Juergen A.
影响因子：
64.5
作者：
Huang, Z;Kunes, S
通讯作者：
Kunes, S
影响因子：
23.9
作者：
Boldrini M;Fulmore CA;Tartt AN;Simeon LR;Pavlova I;Poposka V;Rosoklija GB;Stankov A;Arango V;Dwork AJ;Hen R;Mann JJ
通讯作者：
Mann JJ