Development of vestibular behaviors in zebrafish.

Development of vestibular behaviors in zebrafish.
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DOI:
10.1016/j.conb.2018.06.004
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发表时间:
2018-12
影响因子:
5.7
通讯作者:
Schoppik D
Schoppik D
中科院分区:
医学2区
文献类型:
--
作者:
Bagnall MW;Schoppik D

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大多数动物根据重力来确定身体的方向,以促进运动和感知。负责这些定向运动的神经回路长期以来一直是解决系统神经科学中基本问题的模型。虽然姿势控制至关重要,但我们对平衡反射或产生它们的神经回路的发展知之甚少。最近在遗传学和光学上可接近的脊椎动物,斑马鱼幼体,已经开始揭示这种前庭行为和回路起作用的机制。在这里,我们强调最近的工作,利用特定的优势,幼虫斑马鱼照亮姿势发展的机制,平衡电路发展的感觉的作用,和发展前庭电路的组织。此外,我们框架开放的问题,关于功能电路组装和成熟的发展机制,研究斑马鱼前庭系统可能会开辟新的领域。
Most animals orient their bodies with respect to gravity to facilitate locomotion and perception. The neural circuits responsible for these orienting movements have long served as a model to address fundamental questions in systems neuroscience. Though postural control is vital, we know little about development of either balance reflexes or the neural circuitry that produces them. Recent work in a genetically and optically accessible vertebrate, the larval zebrafish, has begun to reveal the mechanisms by which such vestibular behaviors and circuits come to function. Here we highlight recent work that leverages the particular advantages of the larval zebrafish to illuminate mechanisms of postural development, the role of sensation for balance circuit development, and the organization of developing vestibular circuits. Further, we frame open questions regarding the developmental mechanisms for functional circuit assembly and maturation where studying the zebrafish vestibular system is likely to open new frontiers.
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