Mitochondrial DNAs decreased and correlated with clinical features in HCV patients from Yunnan, China
Mitochondrial DNAs decreased and correlated with clinical features in HCV patients from Yunnan, China
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中国云南 HCV 患者线粒体 DNA 减少并与临床特征相关
DOI：
10.3109/19401736.2015.1036255
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发表时间：
2016-07
期刊：
影响因子：
--
通讯作者：
Xia Xueshan
中科院分区：
文献类型：
--
作者：
Zhang A-Mei;Ma Ke;Song Yuzhu;Feng Yue;Duan Haiping;Zhao Ping;Wang Binghui;Xu Gang;Li Zheng;Xia Xueshan
丙型肝炎是世界范围内最常见的慢性感染性肝病。丙型肝炎病毒（HCV）感染可导致线粒体功能障碍，但其机制尚不完全清楚。为了探讨线粒体DNA拷贝数是否会受到丙型肝炎病毒感染的影响以及与丙型肝炎病毒患者临床特征的相关性，分析了242例丙型肝炎病毒感染患者和226例匹配对照样本的线粒体DNA拷贝数。结果表明，HCV感染组mtDNA拷贝数（68.80 ± 3.33）较对照组（81.54 ± 4.50）明显减少（P = 0.022）。当将男性/女性从总患者中分离出来以将mtDNA拷贝数与性别匹配的对照进行比较时，男性HCV患者的mtDNA拷贝数仍然显著降低（p = 0.002）。进一步分析表明，高密度脂蛋白胆固醇（HDL-C）水平与总HCV患者的mtDNA拷贝数呈负相关（r =-0.128，p = 0.047），这种相关性在男性HCV患者中更为显著（r =-0.266，p = 0.030）。在男性HCV患者中，AST与mtDNA拷贝数呈正相关（r = 0.260，p = 0.034）。我们的研究结果表明，男性HCV患者的mtDNA拷贝数减少，并与临床特征相关。
Abstract Hepatitis C was the most popular chronic infectious liver disease worldwide. It was identified that Hepatitis C virus (HCV) infection could lead to mitochondrial dysfunction, though the mechanism was not fully understood. To investigate whether mtDNA copy number could be affected by HCV infection and be associated with clinical features of HCV patients, mtDNA copy numbers were analyzed in 242 patients with HCV infection and 226 matched control samples. The results suggested that mtDNA copy numbers significantly decreased in HCV patients (68.80 ± 3.33) than in control samples (81.54 ± 4.50) (p = 0.022). When males/females were separated from total patients to compare mtDNA copy numbers with gender matched controls, mtDNA copy numbers still significantly decreased in male HCV patients (p = 0.002). Further analysis indicated that level of high-density lipoprotein cholesterol (HDL-C) was negatively correlated with mtDNA copy numbers in total HCV patients (r = −0.128, p = 0.047), and this correlation was more significant in male HCV patients (r = −0.266, p = 0.030). Intriguingly, aspartate amino-transferase (AST) showed positive correlation with mtDNA copy numbers (r = 0.260, p = 0.034) in male HCV patients. Our results indicated that mtDNA copy numbers depleted and correlated with clinical features in male HCV patients.
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影响因子：
3.2
作者：
Zhang, A-Mei;Ma, Ke;Xia, Xueshan
通讯作者：
Xia, Xueshan
影响因子：
5
作者：
Chang Tan;Hua-bei Guo;Mao-fa Zheng;Y. Chen;Weida Huang
通讯作者：
Chang Tan;Hua-bei Guo;Mao-fa Zheng;Y. Chen;Weida Huang
影响因子：
3.7
作者：
Wang D;Su LY;Zhang AM;Li YY;Li XA;Chen LL;Long H;Yao YG
通讯作者：
Yao YG
影响因子：
4.2
作者：
K. Hino;Yuichi Hara;S. Nishina
通讯作者：
K. Hino;Yuichi Hara;S. Nishina
影响因子：
6.7
作者：
Cubero, Maria;Gregori, Josep;Quer, Josep
通讯作者：
Quer, Josep