Smoking-induced change in intrasynaptic dopamine concentration: effect of treatment for Tobacco Dependence.
Smoking-induced change in intrasynaptic dopamine concentration: effect of treatment for Tobacco Dependence.
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DOI：
10.1016/j.pscychresns.2009.06.004
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发表时间：
2010-09-30
影响因子：
2.3
通讯作者：
Mandelkern, Mark A.
中科院分区：
文献类型：
--
作者：
Brody, Arthur L.;London, Edythe D.;Olmstead, Richard E.;Allen-Martinez, Zoe;Shulenberger, Stephanie;Costello, Matthew R.;Abrams, Anna L.;Scheibal, David;Farahi, Judah;Shoptaw, Steven;Mandelkern, Mark A.
关键词：
The aim of this study was to determine whether standard treatments for Tobacco Dependence affect smoking-induced changes in intrasynaptic dopamine (DA) concentration. Forty-three otherwise healthy adult cigarette smokers (10 to 40 cigarettes per day) were treated with either practical group counseling (PGC) psychotherapy (n = 14), bupropion HCl (n = 14), or matching pill placebo (n = 15) (random assignment) for 8 weeks. Before and after treatment, each subject underwent a bolus-plus-continuous-infusion 11C-raclopride positron emission tomography (PET) scanning session, during which he or she smoked a regular cigarette. The PET scanning outcome measure of interest was percent change in smoking-induced 11C-raclopride binding potential (BPND) in the ventral caudate/nucleus accumbens (VCD/NAc), as an indirect measure of DA release. Although the entire study sample had a smaller mean smoking-induced reduction in VCD/NAc BPND after treatment (compared to before treatment), this change was highly correlated with smaller total cigarette puff volumes (and not other treatment variables). These data indicate that smoking-induced DA release is dose-dependent, and is not significantly affected by reductions in daily smoking levels or treatment type.
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