T-2 toxin-induced toxicity in pregnant mice and rats.
T-2 toxin-induced toxicity in pregnant mice and rats.
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DOI：
10.3390/ijms9112146
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发表时间：
2008-11
影响因子：
5.6
通讯作者：
Sehata S
中科院分区：
文献类型：
--
作者：
Doi K;Ishigami N;Sehata S
T-2毒素是毛霉菌毒素家族中的一种细胞毒性次生真菌代谢产物。这种真菌毒素通过与多肽转移酶的高亲和力而抑制蛋白质的合成，多肽转移酶是核糖体60S亚基的组成部分，它还抑制DNA和RNA的合成，可能仅次于蛋白质合成的抑制。此外，T-2毒素据说可以诱导许多具有高增殖活性的细胞发生凋亡。T-2毒素很容易通过胎盘，分布到胚胎/胎儿组织中，其中包括许多具有高增殖活性的成分细胞。本文综述了有关T-2毒素对妊娠小鼠和大鼠母体和胎儿毒性的报道。本文还对T-2毒素诱导母体和胎儿组织细胞凋亡的机制进行了讨论。
T-2 toxin is a cytotoxic secondary fungal metabolite that belongs to the trichothecene mycotoxin family. This mycotoxin is a well known inhibitor of protein synthesis through its high binding affinity to peptidyl transferase, which is an integral part of the ribosomal 60s subunit, and it also inhibits the synthesis of DNA and RNA, probably secondary to the inhibition of protein synthesis. In addition, T-2 toxin is said to induce apoptosis in many types of cells bearing high proliferating activity. T-2 toxin readily passes the placenta and is distributed to embryo/fetal tissues, which include many component cells bearing high proliferating activity. This paper reviews the reported data related to T-2 toxin-induced maternal and fetal toxicities in pregnant mice and rats. The mechanisms of T-2 toxin-induced apoptosis in maternal and fetal tissues are also discussed in this paper.
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影响因子：
3.5
作者：
Huang, Peixin;Akagawa, Keisuke;Morimoto, Kanehisa
通讯作者：
Morimoto, Kanehisa
影响因子：
3.5
作者：
Annunziato, L;Amoroso, S;Di Renzo, GF
通讯作者：
Di Renzo, GF
影响因子：
2
作者：
Albarenque, SM;Shinozuka, J;Doi, K
通讯作者：
Doi, K
影响因子：
1.6
作者：
Alam, MM;Nagase, M;Sakato, N
通讯作者：
Sakato, N
影响因子：
--
作者：
Albarenque, SM;Suzuki, K;Doi, K
通讯作者：
Doi, K