Preclinical Models for Bladder Cancer Research.
Preclinical Models for Bladder Cancer Research.
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DOI:
10.1016/j.hoc.2021.02.007
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发表时间:
2021-06
期刊:
影响因子:
--
通讯作者:
Pan CX
中科院分区:
文献类型:
--
作者:
Zhu S;Zhu Z;Ma AH;Sonpavde GP;Cheng F;Pan CX
At diagnosis, over 70% of bladder cancers (BC) are at the non-muscle-invasive bladder cancer (NMIBC) stages which are usually treated with transurethral resection followed by intravesical instillation. For the remaining advanced cancers, systemic therapy is the standard of care with addition of radical cystectomy in case of locally advanced cancers. Because of the difference in treatment modalities, different models are needed to advance the care of NMIBC and advanced BC. This article gives a comprehensive review of both in vitro and in vivo BC models and compares the advantages and drawbacks of these preclinical systems in BC research.
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