Necrotizing infundibulo-hypophysitis: an entity too rare to be true?

Necrotizing infundibulo-hypophysitis: an entity too rare to be true?
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DOI:
10.1007/s11102-011-0307-2
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发表时间:
2012-06
期刊:
影响因子:
3.8
通讯作者:
Rohde, Veit
Rohde, Veit
中科院分区:
医学2区
文献类型:
--
作者:
Gutenberg, Angelika;Caturegli, Patrizio;Metz, Imke;Martinez, Ramon;Mohr, Alexander;Brueck, Wolfgang;Rohde, Veit

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我们报告一位年轻女性突然和严重的眶后头痛,颈部疼痛,和一个大鞍肿块延伸到鞍上池。推定诊断为非分泌性垂体大腺瘤发生中风,并经蝶窦手术。组织病理学显示垂体前叶单核浸润和明显的非出血性坏死,符合坏死性垂体炎的诊断。讨论了这种罕见的垂体炎的可能发病机制。
We report a young woman with sudden and severe retroorbital headache, neck pain, and a large sellar mass extending to the suprasellar cistern. A presumptive diagnosis of non-secreting pituitary macroadenoma undergoing apoplexy was made and transphenoidal surgery performed. Histopathology revealed mononuclear infiltration and marked non-hemorrhagic necrosis of the anterior pituitary consistent with a diagnosis of necrotizing infundibulo-hypophysitis. The possible pathogenesis of this rare variant of hypophysitis is discussed.
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