Microsphere skimming in the porcine coronary arteries: Implications for flow quantification.
Microsphere skimming in the porcine coronary arteries: Implications for flow quantification.
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DOI：
10.1016/j.mvr.2015.04.005
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发表时间：
2015-07
影响因子：
3.1
通讯作者：
Smith NP
中科院分区：
文献类型：
--
作者：
Sinclair M;Lee J;Schuster A;Chiribiri A;van den Wijngaard J;van Horssen P;Siebes M;Spaan JA;Nagel E;Smith NP
颗粒撇油是指流体中的悬浮颗粒在流经容器时与流体体积在连接处的分布不成比例的现象。微球被认为是器官内血流灌注测量的金标准，被广泛用于血流分布和定量研究。以前的假设是，动脉连接处的掠过是导致心内膜下微球对心肌血流灌注的系统性高估的原因。我们的目标是结合冠状动脉结构和微球分布，以高分辨率成像，以验证微球在猪左冠状动脉(LCA)网络中掠过的假说。根据冷冻显微成像数据重建了一个详细的网络，并使用泊松叶流模型对流动进行了模拟。使用Clopper-Pearson可信区间的统计方法来确定在LCA的分叉处略读的发生率。结果表明，微球掠过在较大的冠状动脉分叉处最常见，即心外膜动脉和跨壁动脉。识别撇油的分叉具有明显更不对称的分枝参数。这一发现表明，当使用薄的跨壁节段来量化来自微球的血流时，与撇脂相关的沉积偏差可能导致低估心外膜下的灌注量，而高估心内膜下的灌注量。
Particle skimming is a phenomenon where particles suspended in fluid flowing through vessels distribute disproportionately to bulk fluid volume at junctions. Microspheres are considered a gold standard of intraorgan perfusion measurements and are used widely in studies of flow distribution and quantification. It has previously been hypothesised that skimming at arterial junctions is responsible for a systematic overestimation of myocardial perfusion from microspheres at the subendocardium. Our objective is to integrate coronary arterial structure and microsphere distribution, imaged at high resolution, to test the hypothesis of microsphere skimming in a porcine left coronary arterial (LCA) network. A detailed network was reconstructed from cryomicrotome imaging data and a Poiseuille flow model was used to simulate flow. A statistical approach using Clopper–Pearson confidence intervals was applied to determine the prevalence of skimming at bifurcations in the LCA. Results reveal that microsphere skimming is most prevalent at bifurcations in the larger coronary arteries, namely the epicardial and transmural arteries. Bifurcations at which skimming was identified have significantly more asymmetric branching parameters. This finding suggests that when using thin transmural segments to quantify flow from microspheres, a skimming-related deposition bias may result in underestimation of perfusion in the subepicardium, and overestimation in the subendocardium.
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影响因子：
14
作者：
Hsu, Li-Yueh;Groves, Daniel W.;Aletras, Anthony H.;Kellman, Peter;Arai, Andrew E.
通讯作者：
Arai, Andrew E.
影响因子：
4.4
作者：
Christian, Timothy F.;Aletras, Anthony H.;Arai, Andrew E.
通讯作者：
Arai, Andrew E.
影响因子：
--
作者：
CHIEN, S;TVETENSTRAND, CD;SCHMIDSCHONBEIN, GW
通讯作者：
SCHMIDSCHONBEIN, GW
影响因子：
3.3
作者：
BUCKBERG, GD;LUCK, JC;FIXLER, DE
通讯作者：
FIXLER, DE
影响因子：
--
作者：
DELLIMORE, JW;DUNLOP, MJ;CANHAM, PB
通讯作者：
CANHAM, PB